Results 91 to 100 of about 5,895,476 (348)
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Link Prediction in Social Networks: the State-of-the-Art
, 2014 In social networks, link prediction predicts missing links in current networks and new or dissolution links in future networks, is important for mining and analyzing the evolution of social networks.
Wang, Peng +3 more
core +1 more source
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Вестник Северо-Кавказского федерального университета, 2022 The article deals with the increasing role of social entrepreneurship as a socio-economic and organizational phenomenon, the impact of social entrepreneurship on the solution of social problems is presented.
Valery Shapovalov +2 more
doaj
Los problemas sociales y su contextualización en el proceso educativo escolar: una necesidad actual
Actualidades Investigativas en Educación, 2017 Los problemas sociales que aquejan al mundo contemporáneo, tienen un marco propicio para su solución durante el proceso educativo que se desarrolla en la institución escolar.
Osmel Rodríguez Companioni +1 more
doaj +1 more source
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
Social problems as sources of opportunity: antecedents of social entrepreneurship opportunities
Entrepreneurial Business and Economics Review, 2015 Objective: Based on extensive literature review, this paper aims to establish if, why and how, in given environmental and market contexts, social entrepreneurship (SE) opportunities are discovered and exploited.
Agnieszka Żur
doaj +1 more source
The Failed Critique of Personal Accounts [PDF]
, 2001 Even though President Bush's Commission to Strengthen Social Security has yet to produce a specific proposal to establish a personal account option for Social Security, opponents of the idea have already put forward a barrage of objections and criticisms.
Peter Ferrara
core
Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays
FEBS Open Bio, EarlyView.We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani +7 more
wiley +1 more source