Results 91 to 100 of about 17,224,878 (304)

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

open access: yesFEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao   +23 more
wiley   +1 more source

Social problems and the quality of life

open access: yes, 2004
People everywhere want to maximize the quality of their lives. there is widespread agreement that a high qulaity of life requires such things as a good education, free dom from fear of crime, good housing, meaningful work, and good health. a high quality
Lauer, Jeanette C., Lauer, Robert H.
core  

Socio-Demographic Development in Russia: Dynamics and Risks for the Labor Market

open access: yesЭкономика и управление, 2019
Aim. This study aims to analyze major trends in socio-economic development in modern Russia in terms of its socio-economic impact. Tasks. In this study, the authors perform a comparative analysis of the first and second phases of depopulation and ...
Vyacheslav V. Lokosov
doaj  

Design and evaluation of FEBS Education and Training Academy module – Integrating generative artificial intelligence into life‐science education

open access: yesFEBS Open Bio, EarlyView.
Life‐science educators from 14 countries redesigned their own course materials with generative AI in a three‐session, pedagogy‐first FEBS Education and Training Academy workshop built on PICRAT. Among 12 matched respondents, four more reported high confidence in each of five practical domains, and 10 of 13 reported implementing at least one idea ...
Zvonimir Mlinarić, Ali Burak Özkaya
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

open access: yesAging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

'Life is about choices, but external factors often affect outcomes': social work students' reasoning about the origins of social problems [PDF]

open access: yes, 2014
It has been suggested that the emerging generation of social workers tend to be motivated primarily by a perception of the individual as the locus of 'social problems', ignoring the structural factors that shape and constrain the conditions of agency ...
Kirk, Guy   +3 more
core   +1 more source

Problems experienced by families of prisoners and possibility of social assistance and support

open access: yes, 2021
Objectives The purpose of the paper is to show the difficulties experienced by the families of persons serving prison sentences, as well as to analyse the possibilities of social assistance and support for families of prisoners in overcoming these ...
Anna Witkowska-Paleń
core   +1 more source

Self‐Regulated Learning Meets AI: Reinterpreting Self‐Regulation, Co‐Regulation, and Socially Shared Regulation in Human–AI Interaction

open access: yesNew Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
wiley   +1 more source

Luhmann’s Sociological Systems Theory and the Study of Social Problems

open access: yes, 2018
This chapter discusses social problems from the perspective of Niklas Luhmann's sociological systems theory. We argue that his theory provides a rich framework to gain relevant insights for the study of social problems.
Schirmer, Werner,   +1 more
core  

Ethical Foreground and Background in Adult Educator Work

open access: yesNew Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Adult educators work in a complex ethical environment. The very act of contributing to the learning of another is fraught with moral overtones. In this paper we consider the ethical dimensions of adult educator practice by distinguishing the ethical features of the context or ‘background’ of practice from the ethical capabilities and decision ...
Steven Hodge, Sonal Nakar
wiley   +1 more source

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