Results 211 to 220 of about 2,068,129 (355)

Network Ties and Organizational Action: Explaining Variation in Social Service Provision Patterns

, 2022
Brad R. Fulton
openalex   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Analysis of long-term care for older adults in Brazil, Spain, and Portugal: Perspectives and challenges. [PDF]

Aten Primaria
de Oliveira LP, Gutierrez BAO, Chubaci RYS, de Oliveira MLC, Caldas JMP, Salmazo-Silva H.   +5 more
europepmc   +1 more source

STRUCTURAL AND FUNCTIONAL MODEL OF INSTITUTIONAL REGULATION OF THE SYSTEM OF SOCIAL AND ECONOMIC PROVISION OF PERSONS WITH DISABILITIES

, 2017
G. Kazarian
openalex   +2 more sources

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Integration of family planning and nutrition programmes in 64 WHO member states of Africa, Eastern Mediterranean and South-East Asia regions: findings from a survey of Ministry of Health officials. [PDF]

BMJ Glob Health
Shah IH, Ali M, Habib NA, Baloch AA, Ouedraogo L, Aderoba A, Gholbzouri K, Upadhyay MT, Jarathilake A, Fawzi W, Partap U.   +10 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Association between social and built environment characteristics and maternal mortality in 340 Latin America cities: an ecological study from the SALURBAL study. [PDF]

BMJ Public Health
Teixeira Vaz C, Silva UM, Ortigoza A, Perner MS, Alazraqui M, Braverman-Bronstein A, Quistberg DA, de Lima Friche AA, Caiaffa WT.   +8 more
europepmc   +1 more source

Social networking sites (SNS); exploring their uses and associated value for adolescent mothers in Western Australia in terms of social support provision and building social capital

, 2015
Samantha Nolan, Joyce Hendricks, Amanda Towell‐Barnard   +2 more
openalex   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source