Results 91 to 100 of about 12,503,861 (249)

Textbook of Psychiatry First Edition, Draft 2 [PDF]

open access: yes, 2014
This multi-authored collaborative textbook on psychiatry, originally created on Wikibooks, discusses a range of psychiatric disorders, including psychotic, mood and and anxiety disorders, amongst many others.
Fountoulakis, Konstantinos   +26 more
core   +1 more source

Disparities in Mental Health Care: An Annotated Bibliography for Psychiatry Training Programs

open access: yes
Objective: Significant disparities in mental health care exist for patients from minoritized racial and ethnic groups, including decreased access, poorer quality of care received, diagnostic bias, and worse treatment outcomes.
Patterson, Danielle K.   +5 more
core   +1 more source

Increasing Lipid Nanoparticle mRNA Copy Number Improves Transfection Potency

open access: yesAdvanced Materials, EarlyView.
As lipid nanoparticle (LNP) systems are the leading platform for in vivo nucleic acid delivery, improving transfection potency of these systems is of considerable interest. In this work, we explored a post‐mixing formulation method involving a two‐step buffer exchange that increased the number of mRNA copies within each LNP while reducing the number of
Yao Zhang   +12 more
wiley   +1 more source

An Anti‐Amyloidogenic Approach to Specifically Block Memory Consolidation in Mice for Therapeutic Intervention

open access: yesAdvanced Science, EarlyView.
Functional amyloid conversion of the translation regulator CPEB3 is essential for long‐term memory persistence. This study demonstrates that targeting this molecular switch with the anti‐amyloidogenic peptide QBP1 selectively blocks CPEB3 fibrillation without disrupting phase separation.
Paula López‐García   +13 more
wiley   +1 more source

Globalization of Korean Geriatric Psychiatry [PDF]

open access: yes, 2004
The Korean Association for Geriatric Psychiatry was founded in 1994. “2004 IPA Asia Pacific Regional Meeting” was held successfully on 8-11 September in Seoul, Korea.
오병훈
core  

Gonadotropin‐Inhibitory Hormone (GnIH) and Its Receptor GPR147 Mediates Acute Stress‐Induced Activation of the Locus Coeruleus‐SAM Axis

open access: yesAdvanced Science, EarlyView.
ABSTRACT Gonadotropin‐inhibitory hormone (GnIH, also known as RFamide‐related peptide‐3, RFRP‐3) is a hypothalamic neuropeptide that regulates vertebrate reproduction via its receptor GPR147. Although GnIH is known to mediate stress‐induced reproductive suppression, its role in broader stress responses remains unclear.
Jiani Zhang   +18 more
wiley   +1 more source

Rehabilitation in psychiatry as a social problem of science

open access: yesRevista Electrónica Dr. Zoilo E. Marinello Vidaurreta, 2020
Background: serious mental disorders are a health problem related to the socio-political and economic context in which they develop. It is considered that rehabilitation in psychiatry is not possible if this context is not taken into account.Objective ...
Juan Carlos Mirabal-Requena   +2 more
doaj  

Comment: Social Psychiatry: Is it going out of fashion? [PDF]

open access: yesInt J Soc Psychiatry, 2023
Gnanapragasam SN.
europepmc   +1 more source

A Critical Time Window of Neocortex Modulation for Remote Fear Memory in Rats and Humans

open access: yesAdvanced Science, EarlyView.
This study identifies a delayed consolidation window around 18 h after fear learning in the mPFC essential for remote fear memory. VTA dopaminergic input during this window sustains remote memory in rats, while non‐invasive stimulation of homologous human mPFC at the corresponding time selectively weakens remote but not recent fear memory, revealing a ...
Lu Cao   +19 more
wiley   +1 more source

Disrupted TFEB/GDNF–cAMP/ATP Coupling Underlies Astrocytic Dysfunction and Depression in LRRK2 G2019S Parkinson's Mice

open access: yesAdvanced Science, EarlyView.
ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao   +5 more
wiley   +1 more source

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