Results 81 to 90 of about 1,884,358 (314)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Quality Recommendation for Child Welfare

, 2020
In 2014, the Ministry of Social Affairs and Health and the Association of Finnish Local and Regional Authorities issued a quality recommendation for child welfare for the first time (Ministry of Social Affairs and Health Publications 2014:6). The quality
Malja, Marjo, Eriksson, Pia, Petrelius, Päivi, Puustinen-Korhonen, Aila   +3 more
core  

Family and community support among older Chilean adults: the importance of heterogeneous social support sources for quality of life. [PDF]

, 2018
Family and community social networks act as social resources that promote well-being at advanced ages. In this study, we analyze the association between social support received from personal social networks (social support from various family members and
Molina Martínez, Mª Ángeles, Schettini del Moral, Rocío, Gallardo-Peralta, Lorena, Molina Martínez, María Ángeles, Gallardo Peralta, Lorena P., Barrón López de Roda, Ana   +5 more
core   +1 more source

Financial Burdens and Barriers to Care Among Nonelderly Adults With Heart Disease: 2010–2015

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background We examined the prevalence of high burdens and barriers to care among adults with heart disease treatment. Methods and Results The participants were aged 18 to 64 years from the Medical Expenditure Panel Survey–Household Component (MEPS‐HC ...
Didem Bernard, Zhengyi Fang
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Epidermolysis bullosa: how social support affects quality of life

, 2018
Measuring quality of life has become an increasingly important method of evaluating the effect of health and social care interventions. The rare genetic condition epidermolysis bullosa is known to have a deep social impact on people’s quality of life ...
Butterworth, Sondra, Martin, Kate, Mason-Whitehead, Elizabeth, Mitchell, Andrew E. P.   +3 more
core  

Parenting-STAIR Modular: a randomized controlled trial of a trauma-focused parenting intervention for military-connected mothers and their children

Trials
Background Military-connected mothers (MCM; mothers who are either service members or veterans or spouses of a service member or veteran) experience significant trauma exposure associated with post-traumatic stress symptoms and ultimately deficits in ...
Kathrine S. Sullivan, Gina Angelotti, Fan Zhang, Seonyeong Kim, Whitney Wortham, Michael A. Lindsey, James Jaccard, Marylène Cloitre, Susan Timmer, David J. Linkh, Steven L. Lancaster   +10 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Social support, network, and relationships among coaches in different sports: a systematic review

Frontiers in Psychology
IntroductionThe study aims to analyze scientific publications on the association between social networks, social relationships, and social support for sports coaches. It seeks to identify the types and levels of social support provided by various agents,
João Gonçalo Ferreira, João Gonçalo Ferreira, Filipe Rodrigues, Filipe Rodrigues, Pedro Sobreiro, Pedro Sobreiro, Mário Silva, Mário Silva, Fernando Jorge Santos, Fernando Jorge Santos, Fernando Jorge Santos, Gonçalo Carvalho, Gonçalo Carvalho, António Hernández Mendo, José Rodrigues, José Rodrigues   +15 more
doaj   +1 more source