Results 101 to 110 of about 6,448,088 (302)

Sequential Voting Promotes Collective Discovery in Social Recommendation Systems

, 2016
One goal of online social recommendation systems is to harness the wisdom of crowds in order to identify high quality content. Yet the sequential voting mechanisms that are commonly used by these systems are at odds with existing theoretical and ...
Celis, L. Elisa, Kobe, Nathan, Krafft, Peter M.   +2 more
core  

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

The Role of Social Capital in Economic Development. Investigating the Causal Nexus through Structural Equations Models [PDF]

This paper carries out an empirical assessment of the causal nexus connecting social capital’s diverse aspects to the “quality” of economic development in Italy. The analysis accounts for three main social capital dimensions (i.e.
Fabio Sabatini
core   +3 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

ATME—Needs, requirements and cross-sectoral patient journeys of patients with out-of-hospital mechanical ventilation and intensive care in outpatient settings: study protocol for an observational study

BMJ Open
Introduction An increasing number of tracheotomised and/or ventilated patients with high-cost out-of-hospital intensive care needs and, at the same time, a decreasing number of healthcare professionals inevitably lead to challenges in the care of this ...
Antje Schwinger, Andreas Büscher, Gerald Willms, Nahne-Alina Knizia, Josefine Hirschler, Constance Stegbauer, Nathalie Englert, Lara Peters, Hakim A. Bayarassou, Leonie Mallmann   +9 more
doaj   +1 more source

Implementing a clozapine supply service in Australian community pharmacies: barriers and facilitators

Journal of Pharmaceutical Policy and Practice, 2019
Background Clozapine is the most effective antipsychotic for treatment-resistant schizophrenia, although serious adverse effects such as agranulocytosis and cardiomyopathy limit its use.
Bethany Wilson, Sara S. McMillan, Amanda J. Wheeler   +2 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Using a gamified monitoring app to change adolescents’ snack intake: the development of the REWARD app and evaluation design

BMC Public Health, 2016
Background As the snacking pattern of European adolescents is of great concern, effective interventions are necessary. Till now health promotion efforts in children and adolescents have had only limited success in changing adolescents’ eating patterns ...
W. Van Lippevelde, J. Vangeel, N. De Cock, C. Lachat, L. Goossens, K. Beullens, L. Vervoort, C. Braet, L. Maes, S. Eggermont, B. Deforche, J. Van Camp   +11 more
doaj   +1 more source

Social Quality in China

The International Journal of Social Quality, 2018
Since the end of the 1990s, when European scholars put forward the social quality theory, related research has been recently and increasingly carried out in China. At present, Chinese society has entered a new stage of development, and the main demands of the population have gradually changed.
Cui Yan, Huang Yongliang
openaire   +1 more source