Results 141 to 150 of about 125,898 (258)

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Circulating extracellular vesicle microRNAs mediate immune modulation of social behavior in male mice. [PDF]

Nat Commun
Matoba K, Dohi E, Garcia PA, Francis-Oliveira J, Mirramezanializamini M, Berkiks I, Anguiano F, Badrani JH, Fatoba O, Choi EY, See J, Parvez MSA, Kochi T, Ito N, Mitani R, Rose IVL, Imai T, Crossman DK, Pletnikov MV, Witwer KW, Niwa M, Kano SI.   +21 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Quantification and Analysis on Animal Social Behavior

Journal of the Robotics Society of Japan, 2017
Masato S. Abe, Haruna Fujioka
openaire   +2 more sources

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Repeated Stress Escalates Aggression and Activity in Fronto-Limbic Regions in Cntnap2^-/^- Mice. [PDF]

Genes Brain Behav
Hertweck CH, Carter CA, McDaniel SS, Llorach P, Tilton HE, Kodali A, Christoffel DJ, Walsh JJ.   +7 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Automated Profiling of Social Behaviors to Assess the Genetic Basis of Evolution of Aggressive Behaviors in Astyanax mexicanus. [PDF]

J Exp Zool A Ecol Integr Physiol
Mapa R, Choy S, Lapko S, Kimmel A, Carino-Bazan I, Kowalko JE.   +5 more
europepmc   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Defective ventral neurogenesis due to midfetal Chd8 mutation drives autistic-like behavior in mice. [PDF]

Nat Commun
Nitahara K, Kawamura A, Tashiro A, Iwasaki T, Horike SI, Terakawa J, Daikoku T, Higashi K, Kurokawa K, Kato K, Nishiyama M.   +10 more
europepmc   +1 more source