Results 121 to 130 of about 136,465 (300)

Les enjeux de la quantification sanitaire au XXe siècle

Histoire, Médecine et Santé, 2013
Bruno Valat
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Explainability and Uncertainty Quantification in Networks and Social Systems [PDF]

The complexity of deep learning models has motivated the development of explainability approaches within the field of artificial intelligence. However, there are several adjacent fieldsto deep learning where similarly complex models are used to make ...
SOPHIE SADLER
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Model based Social Cohesion Indicator

, 2020
In this chapter a Higher-Order Construct Model is used to construct the Italian Social Cohesion Indicator with the use Elementary ordina Indicators with a suitable quantification and some Latent Variables ...
Gabriella Punziano, Carlo Lauro, Nicola Tedesco, Marina Marino   +3 more
core  

The contemporary definition of university social responsibility with quantifiable sustainability

, 2019
Purpose The university social responsibility (USR) is still in embryonic stage compared to corporate social responsibility (CSR) which is still debatable by researchers.
Kouatli, Issam
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Quantifying reciprocal relationships between poverty and health: combining a causal loop diagram with longitudinal structural equation modelling

International Journal for Equity in Health
Background This study takes on the challenge of quantifying a complex causal loop diagram describing how poverty and health affect each other, and does so using longitudinal data from The Netherlands.
Laurens Reumers, Niels Hameleers, Henk Hilderink, Marleen Bekker, Maria Jansen, Dirk Ruwaard   +5 more
doaj   +1 more source

Exploring social-ecological system resilience in South China Karst: Quantification, interaction and policy implication

Geography and Sustainability
China’s Grain to Green Program (GTGP), which is one of the largest payments for ecosystem services (PES) in the world, has made significant ecological improvements to the environment.
Tiantian Chen, Yuxi Wang, Li Peng
doaj   +1 more source