Results 231 to 240 of about 136,465 (300)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

The posteroventral part of the medial amygdala nucleus glutamatergic neurons encodes conspecifics' individual identity in rodents. [PDF]

Sci Adv
Zheng L, Pan L, Fu X, Wang 王思羽 S, Wu Y, Xiao H, Yang J, Wang 王思雨 S, Yang L, Wu X, Pan F, Yang H, Chen G, Wang H, Wang H.   +14 more
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Correction of eIF4E overactivation rescues translatome imbalance and core ASD-like behaviors in valproic acid-induced offspring mice. [PDF]

Mol Psychiatry
Huang M, Ye H, Xu Y, Xie J, Wang X, Luo Y, Liu P, Ma X, Zhang S, Jiang B, Ye WC, Peng Y, Shi L.   +12 more
europepmc   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Impact of early locus coeruleus lesions in the TgF344 Alzheimer's disease rat model. [PDF]

Alzheimers Dement
Marriott AE, Schroeder JP, Korukonda A, Pate BS, McCann KE, Weinshenker D, Kelberman MA.   +6 more
europepmc   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Prolonged social isolation promotes depressive-like behavior in male and female mice, with sex-related differences in the stress response. [PDF]

Biol Sex Differ
Cepeda Y, Tobar C, Jara N, Carril-Pardo C, Villarroel A, Lagos R, Recabal A, Nova-Lamperti E, Obregón-Rivas AM, Vidal PM, Elizondo-Vega R, Oyarce K.   +11 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Bazedoxifene reverses sexually dimorphic autistic-like abnormalities in biallelic MDGA1-mutant mice. [PDF]

EMBO Mol Med
Kim S, Kim H, Pelayo JP, Alvarez S, Jang G, Kim J, Kim B, Hoelscher VM, Calleja-Pérez B, Jung H, Yang Y, Lee HJ, Lee J, Kim S, de la Peña MJ, Lee Y, Kim S, Han AR, Lee DS, Ji S, Yu W, Kim HM, An JY, Oh WC, Kwon SK, Kim JY, Um JW, Fernández-Jaén A, Ko J.   +28 more
europepmc   +1 more source