Results 211 to 220 of about 136,465 (300)

Targeting notch signaling to restore neural development and behavior in mouse models of ASD. [PDF]

Nat Commun
Hanno Y, Nakanishi M, Takase A, Nomura J, Tanaka M, Iida Y, Tanaka M, Hosokawa H, Ito M, Mikami K, Hozumi K, Miyoshi G, Takumi T, Iijima T.   +13 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Simultaneous measurement of piperacillin, tazobactam and meropenem in patient samples using LC-MS/MS to support β-lactam therapeutic drug monitoring.

Anal Methods
Federico S, Williams S, Wilson RC, Arkel P, Gilchrist MJ, Holmes AH, Rawson TM, Riezk A.   +7 more
europepmc   +1 more source

Aberrant astroglial Kir4.1 activation in the anterior cingulate cortex disrupts neuronal excitability and social behavior. [PDF]

Acta Pharm Sin B
Li Z, Zhang Y, Chen Y, Zhang Y, Pan Y, Wang K, Li C, Zhao X, Hu W, Luo Y, Cheng J, Zhang H, Fukunaga K, Xia Y, Jiang J, Liu X, Han F, Lu Y.   +17 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Cerebellar pathology contributes to neurodevelopmental deficits in spinal muscular atrophy. [PDF]

Brain
Gerstner F, Wittig S, Menedo C, Ruwald S, Carlini MJ, Vankova A, Sowoidnich L, Martín-López G, Dreilich V, Alonso-Collado A, Pagiazitis JG, Aousji O, Grzyb C, Smith AK, Yang M, Roselli F, Mentis GZ, Sumner CJ, Pellizzoni L, Simon CM.   +19 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Remembering the opponent: neuronal activation associated with social memory in zebrafish. [PDF]

Front Vet Sci
Cavallino L, Pedreira ME, Pozzi AG, Scaia MF.   +3 more
europepmc   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Whole-Brain Mapping of Neuronal Activity Associated with Vocal Socialization Behaviors in Adult Mice. [PDF]

eNeuro
Luo SX, Chen SY, Kuo HY, Liu FC.
europepmc   +1 more source