Results 191 to 200 of about 125,898 (258)

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

The posteroventral part of the medial amygdala nucleus glutamatergic neurons encodes conspecifics' individual identity in rodents. [PDF]

Sci Adv
Zheng L, Pan L, Fu X, Wang 王思羽 S, Wu Y, Xiao H, Yang J, Wang 王思雨 S, Yang L, Wu X, Pan F, Yang H, Chen G, Wang H, Wang H.   +14 more
europepmc   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Prolonged social isolation promotes depressive-like behavior in male and female mice, with sex-related differences in the stress response. [PDF]

Biol Sex Differ
Cepeda Y, Tobar C, Jara N, Carril-Pardo C, Villarroel A, Lagos R, Recabal A, Nova-Lamperti E, Obregón-Rivas AM, Vidal PM, Elizondo-Vega R, Oyarce K.   +11 more
europepmc   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Bazedoxifene reverses sexually dimorphic autistic-like abnormalities in biallelic MDGA1-mutant mice. [PDF]

EMBO Mol Med
Kim S, Kim H, Pelayo JP, Alvarez S, Jang G, Kim J, Kim B, Hoelscher VM, Calleja-Pérez B, Jung H, Yang Y, Lee HJ, Lee J, Kim S, de la Peña MJ, Lee Y, Kim S, Han AR, Lee DS, Ji S, Yu W, Kim HM, An JY, Oh WC, Kwon SK, Kim JY, Um JW, Fernández-Jaén A, Ko J.   +28 more
europepmc   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Diffuse white matter abnormality is independently predictive of neurodevelopmental outcomes in preterm infants. [PDF]

Arch Dis Child Fetal Neonatal Ed
Derbie AY, Tamm L, Kline-Fath B, Li H, Harpster K, Merhar SL, He L, Altaye M, Parikh NA.   +8 more
europepmc   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Copper deficiency impairs oligodendrocyte maturation and social behavior via mitophagy and mTOR suppression in ASD. [PDF]

Sci Adv
Usui N, Doi M, Berto S, Matsuoka K, Ishida R, Miyauchi H, Fujiwara Y, Irie K, Toritsuka M, Yamauchi T, Hirai T, Xie MJ, Kayashima Y, Umeda N, Iwata K, Okumura K, Harada T, Katayama T, Tsujii M, Matsuzaki H, Makinodan M, Shimada S.   +21 more
europepmc   +1 more source