Results 131 to 140 of about 14,723,140 (335)
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Civic engagement and corruption in 20 European democracies [PDF]
This paper analyzes the relation between different forms of civic engagement and corruption. This first of all extends earlier analysis linking generalized trust to corruption by incorporating another element from the social capital complex (namely ...
Geys, Benny, Grießhaber, Nicolas
core
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Applying Relation Algebra and RelView to Measures in aSocial Network [PDF]
We present an application of relation algebra to measure players' ‘strength' in a social network with influence between players. In particular, we deal with power, success, and influence of a player as measured by the Hoede-Bakker index, its ...
Agnieszka Rusinowska +2 more
core
Adolescent social networking: should parents and teachers be worried? [PDF]
, 2011 Over the past few years, there has been a significant increase in the number of media stories about social networking. This has also led to a recent upsurge in the amount of empirical research being carried out.
Griffiths, MD, Kuss, DJ
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
TOPLUM VE BiLGi GELiŞiMi ÜZERINE BiR DENEME
Fırat Üniversitesi İlahiyat Fakültesi Dergisi, 2003 Tarihi gelişim sürecinde makro sev~vede ele aldığımı:: bilgi ve toplum ilişkisine bakıldığında, ikincisinin bütün karmaşıklığı ve bilginin gelişimine :emin, ma/:eme sağ/ amasıy/a beraber, bilginin de bir o kadar kapsamlı olduğu ortaya çıkmaktadir ...
A.faruk Sinanoğlu
doaj