Results 141 to 150 of about 14,723,140 (335)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Does it matter what we call them? Labelling people on the basis of notions of intellect [PDF]
, 2006 This paper draws on Social Model theory. It examines the nature of debates about language used to describe people who experience barriers in relation to thinking, remembering and communicating, the role this language fulfils, and its impact upon ...
Rix, Jonathan
core
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Is there a fit between pedagogy and technology in online learning? [PDF]
, 2003 The study followed a group of online lecturers from different disciplines who were engaged in different levels of online teaching. The researchers' experiences with e-learning have indicated there are a variety of ways by which teaching staff approach e ...
Maor, D., Zariski, A.
core +1 more source
Psicologia: Teoria e Pesquisa, 2000 Dans le présent article nous étudions les mécanismes de transmission des difficultés socioaffectives entre les systèmes conjugal et parental sous l'effet d'une part de stress contextuels comme la pauvreté des familles et, d'autre part, des ...
Bigras Marc, Paquette Daniel
doaj
Bangabandhu Sheikh Mujib Medical University JournalBackground: Psychopathology in adolescents, seen as adaptation failure which involves deviations from age-appropriate behaviour, disrupting normal development and social functioning, especially in girls and require special attention.
Tajbina Yasin, Sandeep
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
THEOLOGY AND THE SOCIAL SCIENCES—DISCIPLINE AND ANTIDISCIPLINE
Zygon, 1990 . In this review of papers by E. O. Wilson, Philip Gorski, and Robert Segal, I apply Wilson's description of the relations between a discipline and its antidiscipline (the science just below it in the hierarchy of sciences) to the relations between ...
doaj +2 more sources
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source