Results 161 to 170 of about 10,347,127 (343)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Connected in the street: the relation between online social networks, self-esteem and satisfaction with life among individuals experiencing homelessness

, 2018
Fran Calvo, Xavier Carbonell, Oriol Turró, C. Giralt   +3 more
openalex   +2 more sources

Use of Facebook as a Social Media Platform for Public Relation Tool by Indian Political Parties During Covid-19: A Content Analysis

, 2022
Saakshi Jain, Khagendra Nath Gangai
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Loneliness and self-concept in the relations between Theory of Mind and social anhedonia in adolescents. [PDF]

J Res Adolesc
Chen S, Bosacki S, Talwar V.
europepmc   +1 more source

Three essays on the relation between social performance and firm risk [PDF]

, 2012
Kais Bouslah
openalex  

Correlation Between the Relation to Work and Social Intelligence Among the Mayors in the Slovak Republic

, 2018
Eliška Župová
openalex   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Author Correction: Early social adversity modulates the relation between attention biases and socioemotional behaviour in juvenile macaques. [PDF]

Sci Rep
Rayson H, Massera A, Belluardo M, Ben Hamed S, Ferrari PF.   +4 more
europepmc   +1 more source

How are social norms changing in relation to food waste and sustainability

Cseh, Balázs
openalex   +1 more source