Results 1 to 10 of about 340,207 (263)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Clinical Interventions in Aging, 2015 Vinaya Manchaiah,1 Berth Danermark,2 Tayebeh Ahmadi,3 David Tomé,4 Fei Zhao,5 Qiang Li,6 Rajalakshmi Krishna,7 Per Germundsson8 1Department of Speech and Hearing Sciences, Lamar University, Beaumont, TX, USA; 2Swedish Institute for Disability ...
Manchaiah V +7 more
doaj
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Afetos e representações sociais: contribuições de um diálogo transdisciplinar
Psicologia: Teoria e PesquisaEste texto é resultado de uma pesquisa teórica cujos objetivos foram: explorar a afinidade entre a Teoria do Desenvolvimento Emocional, de Winnicott, e a Teoria das Representações Sociais, de Moscovici, e indicar o papel da afetividade na construção de ...
Carolina Fernandes Pombo-de-Barros +1 more
doaj +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Aids’s Images and Meanings Among Users of the Health Basic Net Services of the Rio de Janeiro County
Psicologia, 2009 The present work aimed at identifying and describing the images and the meanings present in the Aids ́s social representations among women attended in the health basic net. It is a qualitative study based on the social representations theory.
Sérgio Corrêa Marques +2 more
doaj
Victims or Heroes?—Disability Representations in a Hungarian Online News Media Portal
DisabilitiesWhile studies consistently show that the popular media often provide medicalized images of disabled people as “other” or inferior, dynamic societal changes, such as the diffusion of human rights laws, increasing public awareness, and the mediatization of
Carmen Svastics +3 more
doaj +1 more source