Results 141 to 150 of about 2,410,903 (293)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

O arrependimento após a esterilização feminina

Cadernos de Saúde Pública
A esterilização feminina é o método anticoncepcional mais usado pelas mulheres brasileiras, embora este método não seja oferecido pelo sistema de saúde.
Elisabeth Meloni Vieira
doaj  

Le rôle des proches dans le processus de détermination de l’inaptitude de la personne âgée en perte d’autonomie du point de vue des professionnels

Enfances, Familles, Générations, 2010
Establishing the fact of incapacity is both a legal and a clinical process, overseen by laws and professional standards that establish a requirement to consult with family and those closely connected to the individual whose capacities are being assessed.
Catherine Canuel, Yves Couturier, Marie Beaulieu   +2 more
doaj  

[Children's social representation of cancer].

Revista da Escola de Enfermagem da U S P, 2004
This research was motivated by the need to know more about the care of children with cancer. The objective of the study was to discover what the social representation of the child with cancer are. Ten open interviews were conducted with children and teenagers from 9 to 15 years of age. The analysis issues that emerged from the children's discourse were
Cagnin, Elaise Regina Gonçalves, Liston, Noeli Marchioro, Dupas, Giselle   +2 more
openaire   +2 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Le corps adolescent face à la souffrance psychique : enjeux individuels, sociaux et politiques de l’hospitalisation en pédopsychiatrie.

Enfances, Familles, Générations, 2019
Research Framework : In child psychiatric hospitalization services, the bodies of adolescents are suddenly extracted from the public sphere in which they should normally be.
Cristina Figueiredo
doaj  

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Père au foyer : une nouvelle entrée au répertoire du masculin ?

Enfances, Familles, Générations, 2017
Research Framework: Despite advocacy in favour of the equal sharing of domestic labour and family responsibilities, women are still overwhelmingly in charge of childcare and housework; for a man to become a “stay-at-home father” is a reversal of ...
Myriam Chatot
doaj  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source