Results 171 to 180 of about 2,422,593 (295)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Social Representation of Mental Health Disorders in the Italian Big Brother VIP Edition. [PDF]

Behav Sci (Basel)
Scardigno R, Gambarrota R, Centonze L.
europepmc   +1 more source

Social Representation of Dementia: An Analysis of 5,792 Consecutive Cases Evaluated in a Memory Clinic. [PDF]

J Alzheimers Dis, 2017
Cañabate P, Martínez G, Rosende-Roca M, Moreno M, Preckler S, Valero S, Sotolongo O, Hernández I, Alegret M, Ortega G, Espinosa A, Mauleón A, Vargas L, Rodríguez O, Abdelnour C, Sánchez D, Martín E, Ruiz A, Tárraga L, Boada M.   +19 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Social Representation, Stereotypes and Social Identity Pertaining to Nursing Through Children's Drawings: A Qualitative Study. [PDF]

Nurs Res Pract
García-Navarro EB, Cáceres Titos MJ, Pascual IR.   +2 more
europepmc   +1 more source

Social representation of "hearing loss": cross-cultural exploratory study in India, Iran, Portugal, and the UK. [PDF]

Clin Interv Aging, 2015
Manchaiah V, Danermark B, Ahmadi T, Tomé D, Zhao F, Li Q, Krishna R, Germundsson P.   +7 more
europepmc   +1 more source

SOCIAL REPRESENTATION OF SEXUAL VIOLENCE

, 2012
The present study explored the social representations of sexual violence in Sicilian secondary schools students. Regarding the social representation of sexual violence and its possible causes, it appears to be important the limited meaning given to sexual violence referred only to those behaviors that require physical strength, whereas sexual abuse ...
Castiglione C., LICCIARDELLO, Orazio, Rampullo A., Scolla V.   +3 more
openaire   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Creating communities that care: social representation of mental health in two urban poor communities in Ghana. [PDF]

Discov Ment Health
Agyei F, de-Graft Aikins A, Osei-Tutu A, Annor F.   +3 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source