Results 191 to 200 of about 7,977,391 (314)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

The social representations of Covid-19 among primary health care' users in the Federal district, Brazil: A psychosocial approach. [PDF]

PLoS One
Shimizu HE, Gomes AMT, Apostolidis T.
europepmc   +1 more source

How schools can aid children's resilience in disaster settings: The contribution of place attachment, sense of place and social representations theories. [PDF]

Front Psychol, 2022
Pacheco EM, Parrott E, Oktari RS, Joffe H.   +3 more
europepmc   +1 more source

Social Representations of the Diet in Patients with Diabetes Mellitus [PDF]

, 2017
Donovan Casas Patiño, Alejandra Torres, Georgina Contreras Landgrave, Isaac Casas Patiño, María de los Ángeles Maya Martínez   +4 more
openalex   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Social Representations of pregnancy among trans men. [PDF]

Rev Bras Enferm
Pereira DMR, Araújo EC, Oliveira SC, Sousa AR, Espíndola MMM, West MGLN, Ramalho MNA, Cardoso JC.   +7 more
europepmc   +1 more source

Categorizations of Trust and Distrust in the Classifications and Social Representations of Food among Pregnant and Breastfeeding Women in Spain-Applying the Cultural Domains' Pile Sort Technique. [PDF]

Int J Environ Res Public Health, 2023
Muñoz A, Larrea-Killinger C, Fontalba-Navas A, Company-Morales M.   +3 more
europepmc   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Social Representations of Formal Volunteers and Spontaneous Volunteers in Socio-Natural Disaster Risk Management Contexts. [PDF]

Behav Sci (Basel)
Peña-Garay M, Sandoval-Díaz J, Cuadra-Martínez D.   +2 more
europepmc   +1 more source

Sociocultural impacts of COVID-19: A social representations perspective. [PDF]

Tour Manag Perspect, 2021
Wassler P, Talarico C.
europepmc   +1 more source