Results 51 to 60 of about 1,392,816 (307)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Hakikat Dan Nuansa Ketahanan Sosial Masyarakat Banyumas Dalam Lensa Reproduksi Sosial

Jurnal Ketahanan Nasional
The Covid-19 epidemic requires strengthening community resilience to adapt to changing social situations. The research aims to find out the nature and nuances of the dynamics of social resilience in the Banyumas community through changes in priorities ...
Shinta - Prastyanti
doaj   +1 more source

Human sense and plant blindness

Language and Semiotic Studies, 2023
Victoria Welby introduces the concept of “Significs” as a methodology that could bridge the various sciences, theoretical trends, and practices in human experience.
Dellino Dario
doaj   +1 more source

No measure for culture? Value in the new economy [PDF]

, 2010
This paper explores articulations of the value of investment in culture and the arts through a critical discourse analysis of policy documents, reports and academic commentary since 1997.
Adorno, T. W, Arvidsson, A., Belfiore, E., Belfiore, E., Bourdieu, P., Bourdieu, P., Brown, A., Caffentzis, G., Dalla Costa, M., De Angelis, M., De Angelis, M., Dowling, E., Dyer-Witheford, N., Dyer-Witheford, N., Edwards, R., Elson, D., Florida, R., Florida, R., Hardt, M., Hardt, M., Hardt, M., Hesmondhalgh, D., Holden, J., House of Commons, Hyland, M., Jowell, T, Kelly, O., Lazzarato, M., Leadbeater, C., Local Government Association (LGA), Marx, K., Marx, K., Marx, K., Matarasso, E, Mizra, M., Negri, A., Negri, A., Negri, A., Newell, S., Oakley, A., Paltridge, B., Raymond, E., Sennett, R., Tapscott, D., Terranova, T, Wenger, E.   +45 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Medium-scale commercial agriculture and its role in structural transformation, wealth creation and enhanced livelihoods in an African context: Evidence from contemporary Zimbabwe

African Journal on Land Policy and Geospatial Sciences
This paper investigates the extent to which Zimbabwe’s emergent medium-scale commercial farms have the potential to contribute to structural transformation, wealth creation and enhanced livelihoods.
Clement Chipenda
doaj   +1 more source

Social aspects in assisted reproduction [PDF]

Human Reproduction Update, 1999
In-vitro fertilization (IVF) and assisted reproductive techniques have become common practice in many countries today, regulated by established legislation, regulations or by committee-set ethical standards. The rapid evolution and progress of these techniques have revealed certain social issues that have to be addressed.
S J, Fasouliotis, J G, Schenker
openaire   +2 more sources

Saving and reproducing the nation: Struggles around right-wing politics of social reproduction, gender and race in austerity Europe [PDF]

, 2018
This article suggests the analytic lens of cultural, social and national reproduction to understand the centrality of gendered and ethnic relations, in particular a focus on family life in contemporary UK.
Ahmed, Albanese, Alexander, Andrews, Balibar, BBC, Berkovitch, Bezanson, Bhabha, Bhambra, Blom, Blum, Bonizzoni, Bourdieu, Bourdieu, Cameron, Cantle, Children’s Commissioner, Daily Mail, Doty, Dummett, El-Tayeb, Emejulu, Erel, Erel, Erel, Fortier, Fraser, Gramsci, Gutiérrez Rodríguez, Gutiérrez Rodríguez, Hage, Home Office, Institute of Race Relations, Jayawerdena, Jensen, Keskinen, Khan, Kirkup, Kofman, Kofman, Kováts, Kraler, Lareau, Luxton, Mayer, McClintock, McDonagh, Mosse, Mulinari, Pető, Phoenix, Price, Rattansi, Reynolds, Scott, Sirriyeh, Smith, Spierings, The Independent, Topping, Turner, Turner, Umut Erel, Vacchelli, Virdee, Wearing, Weaver, Women's Budget Group, Women's Budget Group and Runnymede Trust, Yuval-Davis, Yuval-Davis   +71 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source