Results 51 to 60 of about 127,898 (261)

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Desire, need and reality: Education and professionalization of elite groups in Brazil

open access: yesCiências Sociais Unisinos, 2018
The objective of this paper is to report a study carried out at three Brazilian universities addressing only production engineering undergraduate courses.
Thais Joi Martins, Julio Cesar Donadone
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

BOLSA FAMÍLIA X SALÁRIO NA REPRODUÇÃO SOCIAL DE FAMÍLIAS POBRES EM BELÉM (PA)

open access: yesRevista de Políticas Públicas, 2018
This article presents the main results and analysis from master’s thesis com- pleted this year, whose aim was to understand how the incomes of labor and Family Grant Program combine or conflict in the social reproduction of the be- neficiaries and the ...
Olga Myrla Tabaranã Silva   +1 more
doaj  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Politicizzare la cura per curare la democrazia

open access: yesSocietàMutamentoPolitica: Rivista Italiana di Sociologia
“Taking care” involves a politics of relationships. Care has both a subjective and a relational dimension: starting from subjectivity, everyone opens up to vulnerability, dependence, fragility. Care is above all a practical path of spillage from the self
Sara Fariello, Irene Strazzeri
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Social determinants of human reproduction [PDF]

open access: yesHuman Reproduction, 2001
Developed countries have experienced both some population growth and unprecedented declines in fertility rates during the last half of the twentieth century. Couples now have fewer than two children on average in most European countries and they tend to postpone these births until a later age.
openaire   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Gender, Production, and the ‘the Transition to Capitalism’: Assessing the Historical Basis for a Unitary Materialist Theory

open access: yesNew Proposals, 2011
: When socialist feminists discussed the potential and pitfalls of Marxism in the “domestic labour debate,” the specific relationship between patriarchy and capital emerged as a defining concern.
Gary Blank
doaj  

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