Results 111 to 120 of about 11,665,905 (313)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

A hundred key questions for the post-2015 development agenda

, 2015
With a new development framework under way and an increasingly urgent need to address political, socioeconomic and environmental issues on a global scale, this is a critical moment for the international development agenda.
United Nations Research Institute for Social Development (UNRISD)
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Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Regulating Social Research: Exploring the Implications of Extending Ethical Review Procedures in Social Research [PDF]

Reflecting on my experience of leading several qualitative research projects to investigate \'sensitive\' topics with potentially \'vulnerable\' participants, this paper considers the impact and consequences of increased ethical regulation in relation to
Margaret Melrose
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The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Design of Teaching and Learning Sequences and Complex Educational Games: A Strategic Proposal for Mobilizing the Model of Educational Reconstruction

Investigações em Ensino de Ciências
The Model of Educational Reconstruction (MER) has been employed in research within the field of Science Education to support educational design, particularly through development research.
Michelle Garcia da Silva, Roberta Smania-Marques, Helaine Sivini Ferreira   +2 more
doaj   +1 more source

Conflicting 'mother-scientist' roles. An innovative application of basket analysis in social research. [PDF]

PLoS One, 2022
Krause E, Tomaszewska R, Pawlicka A.
europepmc   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Social Economy, Community Resilience and the Transition to Sustainability - Goal and Project Description [PDF]

, 2012
This five year summary section of a funding application to the Social Sciences and Humanities Research Council of Canada was prepared by the BC-Alberta Social Economy Research Alliance (BALTA) to successfully seek funding to support a two year ...
BC-Alberta Social Economy Research Alliance (BALTA)
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