Results 111 to 120 of about 35,193,888 (347)
Gerontology, Art, and Activism: Can the Intersection of Art, Social Research, and Community Power Lead to Lasting Change? [PDF]
Gerontologist, 2023 Campbell S +7 more
europepmc +1 more source
Economic Analysis on Business Cycles and Suicide Rate - An Approach from Corporate Behavior - [PDF]
, 2015 経済学 / EconomicsJapan has seen a sharp rise in the suicide rate since 1998, which has since been a major social problem. In addition, the number of those suffering mental disorders has been increasing in recent years.
Economic and Social Research Institute +1 more
core +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Research on Social Engagement with a Rabbitic User Interface [PDF]
, 2009 Companions as interfaces to smart rooms need not only to be easy to interact with, but also to maintain long-term relationships with their users. The FP7-funded project SERA (Social Engagement with Robots and Agents) contributes to knowledge about and ...
Cunningham, Stuart +3 more
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Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Social Economy, Community Resilience and the Transition to Sustainability - List of References [PDF]
, 2012 This list of references was included in BALTA's Partnership Development Grant funding application to the Social Sciences and Humanities Research Council of Canada (SSHRC) and covers a cross-section of theoretical and practical resources related to the ...
BC-Alberta Social Economy Research Alliance (BALTA)
core
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Investigações em Ensino de CiênciasThe Model of Educational Reconstruction (MER) has been employed in research within the field of Science Education to support educational design, particularly through development research.
Michelle Garcia da Silva +2 more
doaj +1 more source
A hundred key questions for the post-2015 development agenda
, 2015 With a new development framework under way and an increasingly urgent need to address political, socioeconomic and environmental issues on a global scale, this is a critical moment for the international development agenda.
United Nations Research Institute for Social Development (UNRISD)
core