Results 51 to 60 of about 5,212,449 (312)
Interpretive Social Research [PDF]
, 2018 This volume is a clear introduction to methods of data collection and analysis in the social sciences, with a special focus on interpretive methods based on a logic of discovering hypotheses and grounded theories. The chief methods presented are participant observation, open interviews and biographical case reconstruction.
openaire +4 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Scottish Social Attitudes Survey, 2006
, 2008 copyright UK Data Service and data collection copyright owner.The Scottish Social Attitudes (SSA) survey was launched by ScotCen Social Research (formerly the Scottish Centre for Social Research) in 1999, following the advent of devolution.
Scottish Centre for Social Research
core +1 more source
A social researcher researching social researchers – Lessons from feminist epistemologies
Qualitative ResearchQualitative research literature discusses how power shapes the interview process and the resulting data and explores the epistemic basis for interview research theoretically. However, processes of negotiating epistemic authority in the interview situation, and in data analysis, are investigated less frequently.
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Forum: Qualitative Social Research, 2003 The theoretical discussion reflects the correspondence and methodological synergy between the narration theory in qualitative social research studies and the concepts of narration applied in object-relation psychoanalysis and psychotraumatology.
Harald Weilnböck
doaj
Handbook of Research on Social Entrepreneurship
, 2010 info:eu-repo/semantics ...
Fayolle, A., Matlay, H.
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Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source