Results 121 to 130 of about 12,811,924 (312)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
CORPORATIVE SOCIAL RESPONSIBILITY, PARTNER OR OPPONENT OF KNOWLEDGE MANAGEMENT? [PDF]
It appeared as an initiative of the big transnational companies in their fight for the maintaining and the improvement of their competitive position, Corporative Social Responsibility imposes itself nowadays as an innovative concept, usually associated ...
Anca Maria HRISTEA
core
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
SOCIAL ENTREPRENEURSHIP AND SOCIAL RESPONSIBILITY: COMPARATIVE STUDY [PDF]
The authors are preoccupied with analyzing the process of social entrepreneurship and the implications and the influence of Corporate Social Responsibility (CSR) on social entrepreneurial process. We will base our researches on two perspectives of social
Cătălina Silvia MITRA (CRIŞAN) +1 more
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Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
STRATEGIES OF CORPORATE SOCIAL RESPONSIBILITY IN THE EUROPEAN UNION [PDF]
The present paper emphasizes the corporate social responsibility (CSR) state and development strategies in the European Union and at the level of the Romanian business environment.
Joldes Cosmin, Iamandi Irina Eugenia
core
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
APA: Denunciation and Accommodation of Abusive Interrogations: A Lesson for World Psychology
Psicologia, 2008 In the wake of the air attacks on the United States in September 2001, counterterrorism policy in the George W. Bush Administration involved psychologists in design and implementation of abusive interrogations of foreign detainees.
Jean Maria Arrigo, Jancis Long
doaj