Results 51 to 60 of about 12,811,924 (312)

New Paradigm of Lean Six Sigma in the 4th Industrial Revolution Era

Kvalita Inovácia Prosperita, 2020
Purpose: In early 2000s Six Sigma and Lean were combined into Lean Six Sigma (LSS), which has been one of the major strategic quality initiatives all over the world.
Sung Hyun Park, Su Mi Dahlgaard-Park, Dong-Chun Kim   +2 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Experiments in social responsibility [PDF]

Nature, 2006
Pursuing drugs for neglected diseases is not a traditional part of the pharmaceutical company portfolio. But Paul Herrling of Novartis finds that it brings welcome changes both within and outside the industry. The Novartis research facility in Singapore, focusing on dengue fever and tuberculosis, reflects a new approach from pharmaceuticals companies ...
openaire   +2 more sources

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Socially Responsible NLP [PDF]

Proceedings of the 2018 Conference of the North American Chapter of the Association for Computational Linguistics: Tutorial Abstracts, 2018
As language technologies have become increasingly prevalent, there is a growing awareness that decisions we make about our data, methods, and tools are often tied up with their impact on people and societies. This tutorial will provide an overview of real-world applications of language technologies and the potential ethical implications associated with
Yulia Tsvetkov, Vinodkumar Prabhakaran, Rob Voigt   +2 more
openaire   +2 more sources

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Effectiveness of an educational asthma management program (CuidAR): the protocol for a cluster-randomized trial in the Brazilian primary healthcare setting

Trials
Background Asthma is one of the most prevalent chronic pulmonary diseases, affecting approximately 20 million Brazilian people. Most patients with asthma in Brazil present with uncontrolled disease, leading to high morbidity and mortality rates ...
Ana Paula Tussi Leite, Géssica Luana Antunes, Amanda Paz Santos, Ingrid Rodrigues Fernandes, Lauren Sezerá Costa, Tássia Rolim Camargo, Camila Bonalume Dall’ Aqua, Fernando Rovedder Boita, Alessandra da Silva Mota, Mariana Motta Dias da Silva, Mariah Prata Soldi Passos Taube, Bruna Silveira da Rosa, Marcus Herbert Jones, Álvaro A. Cruz, Frederico Friedrich, Paulo M. Pitrez   +15 more
doaj   +1 more source

Power as an ethical concern in the Global South’s digital transformation

TATuP – Zeitschrift für Technikfolgenabschätzung in Theorie und Praxis, 2019
The digitalization of the Global South, particularly with respect to African countries, is moving at a fast pace. This can be seen in the use of information and communications technology (ICT) in different domains such as healthcare, education, industry,
Kutoma Wakunuma
doaj   +1 more source