Results 71 to 80 of about 3,252,816 (308)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Exploring potential power of corporate social responsibility toward sustainability development: analysis of state-owned company social responsibility in Indonesia [PDF]

, 2012
The implementation of corporate social responsibility (CSR) in Indonesia is mostly forced to follow government rules. Government also enacted some regulations that all state-owned companies (SOCs) allocate some of their profits in CSR programs.
Frisko, Dianne
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Gauging the impact of community university engagement initiatives in India

ASEAN Journal of Community Engagement, 2017
Today, the world we live inis challenged with the co-existence of ‘prosperity and poverty’. In India, inparticular, although we are witnessing staggering increase in various economicindicators, our Human Development Indicators (HDIs) remain unenviable ...
Wafa Singh
doaj   +1 more source

Innovative Corporate Social Responsibility in Botswana: The Debswana Mining Company Study Case [PDF]

, 2011
This paper presents a study case on innovative corporate social responsibility as a very important aspect of management planning and, in the process, explores some trends and new ideas pertaining to corporate social responsibility in mining industries ...
José Ramon Torres Solís, Keonethebe Moroka   +1 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Reasserting Gija women's role in mine site reclamation: A perspective from the Argyle Diamond Mine

Journal of Political Ecology
The Argyle diamond mine, in the East Kimberley region of Western Australia, ceased production in late 2020 after 37 years of operations and producing 865 million carats of rough diamonds.
Kia Dowell, Sarah Elizabeth Holcombe
doaj   +2 more sources

Corporate Social Responsibility and Workers’ Rights [PDF]

, 2008
[Excerpt] Corporate social responsibility (CSR) brings an important dimension to the global economy. CSR can enhance human rights, labor rights, and labor standards in the workplace by joining consumer power and socially responsible business leadership ...
Compa, Lance A
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Efektivitas Pengolahan Air Limbah Domestik Grey Water Dengan Proses Biofilter Anaerob dan Biofilter Aerob (Studi Kasus: IPAL INBIS Permata Bunda, Bontang)

Jurnal Serambi Engineering, 2020
Domestic wastewater from non toilets is referred to as grey wastewater, domestic wastewater from bathing, washing and from the kitchen. Incubator Bisnis (INBIS) Permata Bunda is a forum for the application of entrepreneurial skills (apprenticeship) for ...
Muhammad Busyairi, Nikita Adriyanti, Abdul Kahar, Dian Nurcahya, Sariyadi Sariyadi   +4 more
doaj   +1 more source