Results 111 to 120 of about 2,390,312 (355)

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

URDU: سیاسی و سماجی معا ملات میں احساسِ ذمہ داری: سیرۃ النبیﷺ کی روشنی میں تعمیری مطالعہ

open access: yesایقان, 2019
Islam readily being a natural religion provides a complete code of conduct to human being. According to Islam, concept of state, the sense of responsibility has too much importance. The essence of responsibility gives birth to social progress and success.
Abdul Rauf   +2 more
doaj   +1 more source

Social responsibility reporting at group level in a mutual insurance company: the experience of ITAS Mutua Assicurazioni

open access: yes, 2009
The Global Reporting Initiative (GRI) guidelines state that a social responsibility re-port should provide information about 'all entities over which the reporting organisa-tion exercises control or significant influence'.
Bazzanella, Claudio   +2 more
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

SELF-PROMOTION OF THE MONOGRAPH "OUTLINE OF THE THEORY OF THE STATE AS AN ECOLOGICALLY SAFE ORGANIZATION IN EMPIRICAL RESEARCH"

open access: yesHumanities and Social Sciences
Four concepts – ecological security, social responsibility, sustainable development, and environmental management – are analyzed to show that the same terminology can represent different meanings and approaches to the development of a state or urban ...
Ewa Jadwiga LIPIŃSKA
doaj   +1 more source

Соціальна відповідальність: теоретико-методологічний аспект аналізу [PDF]

open access: yes, 2009
Андрющенко Аліса Іллівна кандидат філософських наук, доцент кафедри соціології управління і соціальної роботи Харківського національного університету імені В.Н. Каразіна. Рябець Інна Миколаївна- студентка магістратури V курсу соціологічного факультету,
Андрющенко, А.І.   +1 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

The Organization of Public Service Provision [PDF]

open access: yes
This paper addresses the question of how the responsibility for the delivery of social services, including health, education, and welfare programs, should be divided between state and central governments.
Billy Jack
core  

Home - About - Disclaimer - Privacy