Results 171 to 180 of about 308,892 (313)
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Holding Corporate Social Responsibility to account: its applicability in tourism development [PDF]
Tourism was introduced in Elmina and Cape Coast, (Ghana, Africa) home to three World Heritage Sites (slave dungeons during transatlantic slave trade) as a means to poverty reduction. However, almost fifteen years later, this was not achieved.
Koutra, Christina
core
FEBS Open Bio, EarlyView.In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara +3 more
wiley +1 more source
Social Responsibility of Multinational Corporations to Train Their Personnel. An Evaluation of Explanatory Variables for a Telecommunications Company [PDF]
Corporate social responsibility in the field of employee-employer relation has enjoyed a growing attention in recent years. In this context, workplace training plays an essential role for the harmony of interdependence between community and company. This
Basarab Gogoneaţă
core
Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells
FEBS Open Bio, EarlyView.To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai +8 more
wiley +1 more source
Pathways and pitfalls: a qualitative study of student experiences in biomedical science education
FEBS Open Bio, EarlyView.Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell +8 more
wiley +1 more source
Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface
FEBS Open Bio, EarlyView.HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana +5 more
wiley +1 more source
Conceptualizing moral health for military moral injury care: theoretical foundations of the moral engagement group. [PDF]
Front PsychiatryAntal CJ.
europepmc +1 more source
Corporate social responsibility in the first years of Caja de Pensiones para la Vejez y de Ahorros [PDF]
When Caja de Pensiones para la Vejez y de Ahorros, 'la Caixa', was created in 1905, it was not just a transient response to a serious social, political, and economic problem; it also provided a permanent solution by creating a long-lasting social welfare
Moreno, Carlos M. +2 more
core
FEBS Open Bio, EarlyView.NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks +4 more
wiley +1 more source