Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Racial Disparities and Personal Responsibility Incentives in Medicaid. [PDF]
Craig DM +6 more
europepmc +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
The transformative potential of Social and Solidarity Economy in elder care: social needs, social relations and provisioning systems. [PDF]
Adam S +3 more
europepmc +1 more source
The Social Stratification of Social Risks: Class and Responsibility in the 'New' Welfare State [PDF]
Welfare states are said to have evolved over the course of the past twenty years towards a ‘social investment’ model of welfare, characterised by a focus on equality of opportunity and upward social mobility combined with greater emphasis on individual ...
Christopher T. Whelan +3 more
core
Intelligent Tutoring Systems for Adult Learning in STEM Disciplines
ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley +1 more source
Systems-Based Practice Core Competency: A Survey of Physicians' Perspectives. [PDF]
DeWaters AL +16 more
europepmc +1 more source
ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley +1 more source
Between work and care: a comparative study of the trajectories of women from different social classes in Cuba and Argentina. [PDF]
Muñiz Terra L, León DE, Companioni YB.
europepmc +1 more source
Functions of the State in the Implementation of Social Responsibility by State-Owned Enterprises
Nurhaedah Nurhaedah +3 more
openaire +1 more source

