Results 221 to 230 of about 13,797,006 (300)

Understanding violence as a health determinant among ethnic communities in Colombia's Pacific region: a qualitative analysis. [PDF]

Cad Saude Publica
Rocha-Buelvas A, Mogollón-Hernández AP.   +1 more
europepmc   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Growing up digital: respecting children's evolving capacities in times of change. [PDF]

BMJ Paediatr Open
Subrahmanian R, Aptel C, Herczog M, Jhaveri R, Lansdown G, Mercer R, Mezmur BD, Patel V, Sedletzki V, Teixeira C.   +9 more
europepmc   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

The Twilight of Equality and the Birth of Fraternity: A Commentary on Chief Justice Chandrachud’s Historic Address at the 6th Annual Conference on the Unfinished Legacy of Dr. B.R. Ambedkar

Caste
Rajesh Sampath
doaj  

Collective interests, health research ethics and data governance for Indigenous Sámi populations. [PDF]

PLoS Med
Siri SRA, Mienna CS, Axelsson P.
europepmc   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Recovery in Mental Health: A Synthesis of the Perspectives of Experts by Experience, Recovery-Oriented Professionals and Family Caregivers in Relation to the CHIME and SPICE Frameworks. [PDF]

Health Expect
Guerrero E, Barrios M, Sampietro HM, Gómez-Benito J, Guilera G.   +4 more
europepmc   +1 more source