Results 31 to 40 of about 335,048 (263)

Upacicalcet: A Novel Intravenous Calcimimetic Agent for Patients Undergoing Hemodialysis With Secondary Hyperparathyroidism

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving maintenance dialysis, driven by calcium and phosphate metabolism disturbances. Calcimimetics are central to the management of SHPT by enhancing calcium‐sensing receptor sensitivity and reducing parathyroid hormone secretion.
Fumihiko Koiwa, Daisuke Honda, Seigo Akari, Tadao Akizawa   +3 more
wiley   +1 more source

Exploring the sexual and reproductive health and rights policies and their relationship to the Termination of Pregnancy Act (1977) and bodily autonomy and integrity in Zimbabwe: a multimethod research protocol

BMJ Open
Introduction In Zimbabwe, pregnancy termination is generally prohibited unless and only if the circumstances are in sync with the conditions stipulated in the Termination of Pregnancy (ToP) Act of 1977.
Wilfred Njabulo Nunu, Musa Sibindi, Fennie Mantula, Gracsious Maviza, Mthandazo Maphosa, Pofela Ndzozi, Ndabezinhle Gumbo, Violet Rufaro Muparamoto, Farai Masiyambiri, Mojalifa Ndlovu, Emilia Nhorido, Shantel Ndebele   +11 more
doaj   +1 more source

Applying the Innov8 approach for reviewing national health programmes to leave no one behind: lessons learnt from Indonesia

Global Health Action, 2018
The World Health Organization’s Innov8 Approach for Reviewing National Health Programmes to Leave No One Behind is an eight-step process that supports the operationalization of the Sustainable Development Goals’ commitment to ‘leave no one behind’.
Theadora Swift Koller, Victoria Saint, Rustini Floranita, Gita Maya Koemara Sakti, Imran Pambudi, Lukas Hermawan, Benedicte Briot, Patricia Frenz, Orielle Solar, Pilar Campos, Eugenio Villar, Veronica Magar   +11 more
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Impact of Integrating Social and Health Home Care Services in Catalonia: A Retrospective Cohort-Based Two-Year Study

International Journal of Integrated Care
Introduction: This study aimed to evaluate the impact of integrating social and health home care services (HCSs) on institutionalization, survival, and utilization of health and social care services and associated expenditures.
Emili Vela, Joan Carles Contel, Anna Vila, Sebastià J. Santaeugènia, Rosa Suñol, Jordi Amblàs-Novellas, Conxita Barbeta, Aina Plaza, Pilar Hilarión   +8 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Felicidad y constitucionalismo = Happiness and constitutionalism

Revista de Derecho Político, 2013
La importancia de la felicidad, y su oportuna vinculación con la justicia, ha sido puesta de manifiesto desde el pensamiento filosófico clásico griego.
María Isabel Lorca Martín de Villodres
doaj   +1 more source

Social Rights as Transindividual Rights

, 2022
The thesis at hand assesses how social rights have been conceived and legally addressed during the late financial crisis in Europe and against the austerity backdrop in Greece and Portugal by fostering a critical, comparative, and interdisciplinary approach from a law and ethics perspective.
openaire   +2 more sources

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source