Results 51 to 60 of about 610,169 (309)

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Exploring the sexual and reproductive health and rights policies and their relationship to the Termination of Pregnancy Act (1977) and bodily autonomy and integrity in Zimbabwe: a multimethod research protocol

BMJ Open
Introduction In Zimbabwe, pregnancy termination is generally prohibited unless and only if the circumstances are in sync with the conditions stipulated in the Termination of Pregnancy (ToP) Act of 1977.
Wilfred Njabulo Nunu, Musa Sibindi, Fennie Mantula, Gracsious Maviza, Mthandazo Maphosa, Pofela Ndzozi, Ndabezinhle Gumbo, Violet Rufaro Muparamoto, Farai Masiyambiri, Mojalifa Ndlovu, Emilia Nhorido, Shantel Ndebele   +11 more
doaj   +1 more source

Leadership for a Fractured World: How to Cross Boundaries, Build Bridges, and Lead Change,

Norteamérica, 2016
  The book review is on Harvard Professor Dean Williams´latest book regarding leadership in a cross cultural perspective. As a member of the Center for Public Leadership at the Harvard Kennedy School, Prof Williams has extensively written about the ...
Alexandra Aguilar Bellamy
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Applying the Innov8 approach for reviewing national health programmes to leave no one behind: lessons learnt from Indonesia

Global Health Action, 2018
The World Health Organization’s Innov8 Approach for Reviewing National Health Programmes to Leave No One Behind is an eight-step process that supports the operationalization of the Sustainable Development Goals’ commitment to ‘leave no one behind’.
Theadora Swift Koller, Victoria Saint, Rustini Floranita, Gita Maya Koemara Sakti, Imran Pambudi, Lukas Hermawan, Benedicte Briot, Patricia Frenz, Orielle Solar, Pilar Campos, Eugenio Villar, Veronica Magar   +11 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Impact of Integrating Social and Health Home Care Services in Catalonia: A Retrospective Cohort-Based Two-Year Study

International Journal of Integrated Care
Introduction: This study aimed to evaluate the impact of integrating social and health home care services (HCSs) on institutionalization, survival, and utilization of health and social care services and associated expenditures.
Emili Vela, Joan Carles Contel, Anna Vila, Sebastià J. Santaeugènia, Rosa Suñol, Jordi Amblàs-Novellas, Conxita Barbeta, Aina Plaza, Pilar Hilarión   +8 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Impact of neighborhood context on self-rated health among very old adults living in Germany: a cross-sectional representative study

BMC Geriatrics
Background Increasingly, evidence has shown that different aspects of neighborhood context play a significant role in self-rated health, one of the key health indicators in advanced age.
Jaroslava Zimmermann
doaj   +1 more source