Results 71 to 80 of about 12,144,864 (252)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

Modeling Human-Robot Interaction Based on Generic Interaction Patterns [PDF]

open access: yes, 2010
Peltason J, Wrede B. Modeling Human-Robot Interaction Based on Generic Interaction Patterns. In: AAAI Fall Symposium: Dialog with Robots. Arlington, VA, USA: AAAI Press; 2010.While human-robot interaction is typically limited to restrictive command ...
Peltason, Julia   +1 more
core  

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

open access: yesFEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana   +5 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

open access: yesFEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks   +4 more
wiley   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

open access: yesFEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez   +6 more
wiley   +1 more source

The impact of action descriptions on attribution of moral responsibility towards robots

open access: yesScientific Reports
In the era of renewed fascination with AI and robotics, one needs to address questions related to their societal impact, particularly in terms of moral responsibility and intentionality.
Ziggy O’Reilly   +2 more
doaj   +1 more source

Thai Dance Training-Assist Robot [PDF]

open access: yes, 2007
This paper presents an overview of a research project concerning the investigation and development of a Thai Dance Training-Assist Robot. The initial phase of the project consists of literature review on backgrounds of robots, robotic applications and ...
Depickere, A.   +3 more
core  

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

open access: yesFEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty   +13 more
wiley   +1 more source

Predicting humor effectiveness of robots for human line cutting

open access: yesFrontiers in Robotics and AI
It is extremely challenging for security guard robots to independently stop human line-cutting behavior. We propose addressing this issue by using humorous phrases. First, we created a dataset and built a humor effectiveness predictor. Using a simulator,
Yuto Ushijima   +2 more
doaj   +1 more source

Wearable Affective Robot

open access: yesIEEE Access, 2018
With the development of the artificial intelligence (AI), the AI applications have influenced and changed people's daily life greatly. Here, a wearable affective robot that integrates the affective robot, social robot, brain wearable, and Wearable 2.0 is
Min Chen   +4 more
doaj   +1 more source

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