Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
THE MODERN CONDITION OF PROBLEM OF EMOTIONAL BURNOUT IN THE PSYCHOLOGICAL SCIENCE
Вестник университета, 2019 The article describes the emotional burnout. The author’s analyzes various theories and come to the conclusion that various factors at work can lead this syndrome. In addition, the article reveals the ways how to fight this syndrome - the different kinds
V. Knyazev, K. Remizova
doaj
The "Self" under COVID-19: Social role disruptions, self-authenticity and present-focused coping. [PDF]
PLoS One, 2021 Liu JJ, Dalton AN, Lee J.
europepmc +1 more source
The Role of Social Capital in Financial Development [PDF]
To identify the effect of social capital on financial development, we exploit the well-known differences in social capital and trust (Banfield (1958), Putnam (1993)) across different parts of Italy, using microeconomic data on households and firms.
Luigi Guiso +2 more
core
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
The New Role of Corporate Social Responsibility in the Digital Age [PDF]
, 2019 In 2018, Nike, Inc. and Colin Kaepernick released the ad “Believe in something. Even if it means sacrificing everything.” Within hours, the ad went viral, angering some while drawing praise from many others.
Grebisz, Isaac
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The Role of Choice in Social Dilemma Experiments [PDF]
On the basis of problems related to asymmetric information, self-governance has been proposed and often empirically found to be superior to the external imposition of rules in social dilemma situations.
Frank P. Maier-Rigaud, Jose Apesteguia
core +3 more sources
Association between time of residence and self-perception of distress, interpersonal relationships, and social role in Venezuelan immigrants in Lima, Peru 2018-19: mixed-methods study. [PDF]
BMC Public Health, 2022 Delgado-Cáceres FM +2 more
europepmc +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source