Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser+11 more
wiley +1 more source
Interrupted time series datasets from studies investigating the impact of interventions or exposures in public health and social science: a data note. [PDF]
Turner SL+4 more
europepmc +1 more source
John E. Pomfret
openalex +1 more source
The role of administrative data in the big data revolution in social science research.
R. Connelly+3 more
semanticscholar +1 more source
Germline variants in CDKN2A wild‐type melanoma prone families
Among melanoma‐prone families, wild‐type for CDKN2A and CDK4, some have pathogenic variants in genes not usually linked to melanoma. Furthermore, rare XP‐related variants and variants in MC1R are enriched in such families. Germline pathogenic variants in CDKN2A are well established as an underlying cause of familial malignant melanoma. While pathogenic
Gjertrud T. Iversen+5 more
wiley +1 more source
A social science: Using psychoneuroimmunology principles to promote career longevity, productivity, and meaning. [PDF]
Madison AA.
europepmc +1 more source
Investigations in Progress in the United States in the Field of Latin-American Humanistic and Social Science Studies [PDF]
Madaliné W. Nichols
openalex +1 more source
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu+11 more
wiley +1 more source