Results 321 to 330 of about 16,775,741 (374)

NMR screening of low molecular weight inhibitors targeting the papain‐like protease (PLPro) of SARS‐CoV‐2

FEBS Open Bio, EarlyView.
Papain‐like protease from SARS‐CoV‐2 plays an important role in the cleavage of the viral polyproteins and in the suppression of the host's immune response. Here, we present the results of an NMR screening study. We identified 86 binding compounds, of which five candidates were chosen for in‐depth analysis.
Dennis J. Pyper, Sridhar Sreeramulu, Benjamin T. Lanham, Elizabeth M. Engle, David Fushman, Harald Schwalbe   +5 more
wiley   +1 more source

CD9‐association with PIP2 areas is regulated by a CD9 salt bridge

FEBS Open Bio, EarlyView.
The tetraspanin CD9 has an intracellular salt bridge. If CD9 opens, open‐CD9 moves from PIP2‐rich areas to regions populated by its interaction partner EWI‐2. Hence, the state of the salt bridge regulates the distribution of CD9 and by this CD9‐EWI‐2 complex formation.
Yahya Homsi, Sara C. Konopka, Thorsten Lang   +2 more
wiley   +1 more source

Looking beyond effectiveness: Integration of social science research within international infectious disease research in primary care. [PDF]

Eur J Gen Pract
Anthierens S.
europepmc   +1 more source

Characterization of WAC interactions with R2TP and TTT chaperone complexes linking glucose and glutamine availability to mTORC1 activity

FEBS Open Bio, EarlyView.
TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo, Natalia Cuervo, Carmen García‐Martín, Andrés López‐Perrote, Clara Reglero, Adrián Maqueda‐Real, Ana González‐Corpas, Marina Serna, Diego Megías, Alejo Efeyan, Solip Park, Oscar Llorca   +11 more
wiley   +1 more source

Essential Factors on Effective Response at the Onset of the COVID-19 Pandemic Comment on "Experiences and Implications of the First Wave of the COVID-19 Emergency in Italy: A Social Science Perspective". [PDF]

Int J Health Policy Manag
Cortes J, Pacheco M, Fronteira I.
europepmc   +1 more source

The Reddit cannabis subjective highness rating scale: Applying computational social science to explore psychological and environmental correlates of naturalistic cannabis use. [PDF]

PLoS One
Meacham MC, Nobles AL, Bone C', Gilbert M, Thrul J.   +4 more
europepmc   +1 more source

Smoke on the horizon: leveling up citizen and social science to motivate health protective responses during wildfires. [PDF]

Humanit Soc Sci Commun
Prince SE, Muskin SE, Kramer SJ, Huang S, Blakey T, Rappold AG.   +5 more
europepmc   +1 more source

Advances in Social Science Research Using R [PDF]

Carolin Strobl
core   +1 more source

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AI and the transformation of social science research

Science, 2023
Careful bias management and data fidelity are key Advances in artificial intelligence (AI), particularly large language models (LLMs), are substantially affecting social science research. These transformer-based machine-learning models pretrained on vast
I. Grossmann, M. Feinberg, D. C. Parker, N. Christakis, P. Tetlock, William A. Cunningham   +5 more
semanticscholar   +1 more source

Computational social science: Obstacles and opportunities

Science, 2020
Data sharing, research ethics, and incentives must improve The field of computational social science (CSS) has exploded in prominence over the past decade, with thousands of papers published using observational data, experimental designs, and large-scale
D. Lazer, A. Pentland, D. Watts, Sinan Aral, S. Athey, N. Contractor, Deen Freelon, Sandra González-Bailón, Gary King, H. Margetts, Alondra Nelson, Matthew J. Salganik, M. Strohmaier, A. Vespignani, Claudia Wagner   +14 more
semanticscholar   +1 more source