Results 131 to 140 of about 12,433,729 (358)
KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells
Molecular Oncology, EarlyView.We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock +10 more
wiley +1 more source
iScienceSummary: Expressions in social media can provide a rapid insight into people’s reactions to events, such as periods of climatic stress. This study explored the link between climatic stressors and negative sentiment on the X platform in Germany to inform ...
Tareq Al-Ahdal +6 more
doaj
American Journal of Islam and Society, 2002 DHAOUADI: Based on my own observations and impressions, one talks more about sociology as a discipline having a crisis, than about psychology or political science. How do you respond to that? SMELSER: I heard this kind of talk among sociologists.
Mahmoud Dhaouadi
doaj
Public budgets. Edited By Prof. Augustus R. Hatton. Philadelphia: American Academy of Political and Social Science. 1915 [PDF]
, 1916 Lent D. Upgon
openalex +1 more source
Social Science Is Necessary for Operationalizing Socially Responsible Foundation Models [PDF]
arXivWith the rise of foundation models, there is growing concern about their potential social impacts. Social science has a long history of studying the social impacts of transformative technologies in terms of pre-existing systems of power and how these systems are disrupted or reinforced by new technologies. In this position paper, we build on prior work
arxiv
Molecular Oncology, EarlyView.CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar +4 more
wiley +1 more source
Beyond human-likeness: Socialness is more influential when attributing mental states to robots
iScienceSummary: We sought to replicate and expand previous work showing that the more human-like a robot appears, the more willing people are to attribute mind-like capabilities and socially engage with it. Forty-two participants played games against a human, a
Laura E. Jastrzab +4 more
doaj
Molecular Oncology, EarlyView.Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy +12 more
wiley +1 more source
Computer science is a social science.
, 2019 Computer science can, and never will be the same again.
openaire +2 more sources
Molecular Oncology, EarlyView.Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti +8 more
wiley +1 more source