Results 201 to 210 of about 6,022,409 (321)

Together, No. 10 [PDF]

, 2016
San Jose State University, College of Social Sciences
core   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Editors-in-chief in social sciences: Mapping the institutional, geographical, and gender representation between academic fields. [PDF]

PLoS One
Goyanes M, de-Marcos L, Durotoye T, Kurniasari T, Gil de Zúñiga H.   +4 more
europepmc   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Attributing climate-change-related disaster displacement responsibilities along global production chains

iScience
Summary: Climate change creates hostile living conditions in various regions, provoking climate-driven migration. The literature points to a polarization between the countries responsible for climate change and the regions suffering its consequences ...
Guadalupe Arce, Ángela García-Alaminos, Mateo Ortiz, Jorge Zafrilla   +3 more
doaj  

Together, No. 2 [PDF]

, 2012
San Jose State University, College of Social Sciences
core   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

COVID-19 test-to-stay program for K-12 schools: Opt-in versus opt-out consent model

iScience
Summary: The Centers for Disease Control and Prevention promoted the Test-to-Stay (TTS) program to facilitate in-person instruction in K-12 schools during COVID-19.
Anton Ivanov, Ujjal Kumar Mukherjee, Subhonmesh Bose, Sridhar Seshadri, Ronald Watkins, Albert Charles England, Jacqueline Suriano, Mehmet Eren Ahsen, Sebastian Souyris   +8 more
doaj  

Pandemic preparedness: why humanities and social sciences matter. [PDF]

Front Public Health
Frampton S, Orievulu K, Matthews PC, Giubilini A, Hordern J, Burns L, Elias S, Friederich E, Majozi N, Martin S, Stevenson A, Vanderslott S, Seeley J.   +12 more
europepmc   +1 more source

Toward Coequality of the Social Sciences in the National Climate Assessment. [PDF]

Weather Clim Soc, 2022
Maxwell K, Eisenhauer E, Lustig A.
europepmc   +1 more source