Results 201 to 210 of about 6,448,019 (366)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Ten facts from critical and interpretive social sciences for environmental research. [PDF]

iScience
Montana J, Welden EA, Anderson LM, Bennett A, Byfuglien A, Bhalla S, Fair H, Greenhough B, Hafferty C, Hirons M, Kumeh EM, Maguire-Rajpaul V, McDermott CL, Mulyani M, Picot L.   +14 more
europepmc   +1 more source

Reproducibility in the Social Sciences. [PDF]

Annu Rev Sociol, 2022
Moody JW, Keister LA, Ramos MC.
europepmc   +1 more source

Social Problems and Social Science [PDF]

Science, 1966
openaire   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Impostor phenomenon and its association with perceived stress and anxiety among students in medical and social sciences at a Swedish university. [PDF]

Front Med (Lausanne)
Jansson A, Boman J, Schéle I, Holmström S, Rozental A, Semb O, Fahlström M, Stenman L, Bitar A, Lindquist D.   +9 more
europepmc   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Confounding the Grim Reaper: An Evaluation of Some Criticisms of Educational and Social Science Research

, 1988
D. C. Phillips
openalex   +1 more source

The social sciences in climate assessments in the United States. [PDF]

Clim Change
Maxwell KB, Shacklette M, Eisenhauer E, Scheetz AA, Marino E, Zycherman A.   +5 more
europepmc   +1 more source

Short text classification with machine learning in the social sciences: The case of climate change on Twitter. [PDF]

PLoS One, 2023
Shyrokykh K, Girnyk M, Dellmuth L.
europepmc   +1 more source