Results 61 to 70 of about 6,071,023 (341)
FEBS Letters, EarlyView.This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao +7 more
wiley +1 more source
, 2008 https://nsuworks.nova.edu/shss_dialogs/1010/thumbnail ...
Graduate School of Humanities & Social Sciences
core +1 more source
Science and Social Media [PDF]
Stem Cells Translational Medicine, 2019 Summary He Jiankui et al. conducted an experiment that resulted in the birth of the first human babies with germline gene editing. Initial and predominant communications of their work occurred via social media and outside of the norms for reviewing, approving, and engaging around work in science.
openaire +3 more sources
Single‐cell insights into the role of T cells in B‐cell malignancies
FEBS Letters, EarlyView.Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley +1 more source
, 2010 https://nsuworks.nova.edu/shss_dialogs/1007/thumbnail ...
Graduate School of Humanities & Social Sciences
core +1 more source
FEBS Letters, EarlyView.In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi +5 more
wiley +1 more source
, 2013 https://nsuworks.nova.edu/shss_dialogs/1001/thumbnail ...
Graduate School of Humanities & Social Sciences
core +1 more source
Annual Review of Sociology, 2017 Across the medical and social sciences, new discussions about replication have been transforming research practices. Sociologists, however, have been largely absent from these discussions. The goals of this review are to introduce sociologists to these developments, synthesize insights from science studies about replication in general, and detail the ...
Freese, Jeremy, Peterson, David
openaire +4 more sources
Cyclic nucleotide signaling as a drug target in retinitis pigmentosa
FEBS Letters, EarlyView.Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää +2 more
wiley +1 more source
Exploring informed consent in HIV clinical trials: A case study in Uganda
Heliyon, 2016 Introduction: In settings with low literacy levels ensuring that participants are fully-informed before they consent to participate in clinical trials is a challenge.
Agnes Ssali, Fiona Poland, Janet Seeley
doaj +1 more source