Results 61 to 70 of about 12,433,729 (358)

Mainstreaming the social sciences in conservation

open access: yesConservation Biology, 2017
Despite broad recognition of the value of social sciences and increasingly vocal calls for better engagement with the human element of conservation, the conservation social sciences remain misunderstood and underutilized in practice.
N. Bennett   +15 more
semanticscholar   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

open access: yesFEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Unconventional mRNA processing and degradation pathways for the polycistronic yrzI (spyTA) mRNA in Bacillus subtilis

open access: yesFEBS Letters, EarlyView.
The S1025 peptide is the major antidote to the YrzI toxin, which we renamed here as SpyT (Small Peptide YrzI Toxin) and SpyA (Small Peptide YrzI Antitoxin) (1). Degradation of the toxin–antitoxin spyTA mRNA, either by a translation‐dependent cleavage by the endoribonuclease Rae1 (2) or by direct attack by 3′‐exoribonucleases (3), also contributes to ...
Laetitia Gilet   +4 more
wiley   +1 more source

Towards the social media studies of science: social media metrics, present and future [PDF]

open access: yesBibliotecas. Anales de Investigacion. 2017. 13(1), 1-5, 2018
In this paper we aim at providing a general reflection around the present and future of social media metrics (or altmetrics) and how they could evolve into a new discipline focused on the study of the relationships and interactions between science and social media, in what could be seen as the social media studies of science.
arxiv  

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

Science is not a Social Opinion [PDF]

open access: yesDentistry Journal, 2019
Recently, the main American associations in the dental field reported concerns regarding a film on the Netflix, Amazon, Apple, and Vimeo platforms that reported that endodontic treatments of root canals are linked to serious systemic pathologies, against any scientific evidence.
openaire   +5 more sources

A Model of Text for Experimentation in the Social Sciences

open access: yes, 2016
Statistical models of text have become increasingly popular in statistics and computer science as a method of exploring large document collections. Social scientists often want to move beyond exploration, to measurement and experimentation, and make ...
Margaret E. Roberts   +2 more
semanticscholar   +1 more source

Facebook as a research tool for the social sciences: Opportunities, challenges, ethical considerations, and practical guidelines.

open access: yesAmerican Psychologist, 2015
Facebook is rapidly gaining recognition as a powerful research tool for the social sciences. It constitutes a large and diverse pool of participants, who can be selectively recruited for both online and offline studies.
Michal Kosinski   +4 more
semanticscholar   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

open access: yesFEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla   +9 more
wiley   +1 more source

Exploring informed consent in HIV clinical trials: A case study in Uganda

open access: yesHeliyon, 2016
Introduction: In settings with low literacy levels ensuring that participants are fully-informed before they consent to participate in clinical trials is a challenge.
Agnes Ssali, Fiona Poland, Janet Seeley
doaj   +1 more source

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