Results 91 to 100 of about 733,596 (345)

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Installing Digital Culture in Humanities and Social Sciences

[sic], 2019
In an age when social media dominate everyday lives of many people across the globe and with the rise of VR games, Netflix, fake news, and 3D printers, it is evident that (digital) technology has become an integral part of everyday life.
Zlatko Bukač
doaj   +1 more source

Brucella NyxA and NyxB dimerization enhances effector function during infection

FEBS Letters, EarlyView.
Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre, Arthur Louche, Francine C. A. Gérard, Laurent Terradot, Suzana P. Salcedo   +4 more
wiley   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source

Przedmioty humanistyczno-społeczne na uniwersyteckiej uczelni technicznej – założenia i praktyka

Filozofia Publiczna i Edukacja Demokratyczna, 2014
In the article the authors analyze to what extend the participation of the University in the Bologna Process supports teaching humanities and social sciences and what difficulties it might cause.
Bożena Dydycz, Dariusz Zienkiewicz
doaj   +1 more source

Beyond technology: A research agenda for social sciences and humanities research on renewable energy in Europe

Energy Research & Social Science, 2022
S. Krupnik, A. Wagner, O. Koretskaya, T.J. Rudek, R. Wade, M. Mišík, S. Akerboom, C. Foulds, K. Smith Stegen, C. Adem, S. Batel, F. Rabitz, C. Certomà, J. Chodkowska-Miszczuk, M. Denac, D. Dokupilová, M. Leiren, M. Ignatieva, D. Gabaldón-Estevan, A. Horta, P. Karnøe, J. Lilliestam, D. Loorbach, S. Mühlemeier, S. Némoz, M. Nilsson, J. Osička, L. Papamikrouli, L. Pellizioni, S. B. Sareen, M. Sarrica, G. Seyfang, Benjamin Sovacool, A. Telešienė, V. Zapletalová, T. von Wirth   +35 more
semanticscholar   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

The thioredoxin‐like and one glutaredoxin domain are required to rescue the iron‐starvation phenotype of HeLa GLRX3 knock out cells

FEBS Letters, EarlyView.
Glutaredoxin (Grx) 3 proteins contain a thioredoxin domain and one to three class II Grx domains. These proteins play a crucial role in iron homeostasis in eukaryotic cells. In human Grx3, at least one of the two Grx domains, together with the thioredoxin domain, is essential for its function in iron metabolism.
Laura Magdalena Jordt, Manuela Gellert, Finja Zelms, Sander Bekeschus, Christopher Horst Lillig   +4 more
wiley   +1 more source

P‐glycoprotein modulates the fluidity gradient of the plasma membrane of multidrug resistant CHO cells

FEBS Letters, EarlyView.
To explore the impact of the overexpression of the multidrug‐transporter P‐glycoprotein (ABCB1) on membrane fluidity, we compared the transversal gradient of mobility and microviscosity in plasma membranes of drug‐sensitive Chinese hamster ovary cells (AuxB1) and their multidrug‐resistant derivatives (B30) using the fluorescent n‐(9‐anthroyloxy) fatty ...
Roger Busche, John R. Riordan, Burkhard Tümmler   +2 more
wiley   +1 more source

Étude croisée du rapport aux savoirs à l’égard des sciences naturelles et des sciences humaines et sociales : portraits d’élèves de la fin du secondaire au Québec

Recherches en Éducation, 2018
This article offers a cross study of the relationship to knowledge regarding the natural sciences and the humanities and social sciences, from the point of view of secondary school students in Quebec.
Geneviève Therriault, Agnieszka Jeziorski, Barbara Bader, Émilie Morin   +3 more
doaj   +1 more source