Results 81 to 90 of about 733,596 (345)

A cellular system to study responses to a collision between the transcription complex and a protein‐bound nick in the DNA template

FEBS Letters, EarlyView.
We present the cellular transcription‐coupled Flp‐nick system allowing the introduction of a Top1‐mimicking cleavage complex (Flpcc) at a Flp recognition target site within a controllable LacZ gene. LacZ transcription leads to the collision of RNA polymerase II (RNAPII) with Flpcc, and this causes RNAPII stalling, ubiquitination, and degradation.
Petra Herring, Morten Roedgaard, Camilla Myrup Holst, Helene Christensen, Birgitta R. Knudsen, Lotte Bjergbaek, Anni Hangaard Andersen   +6 more
wiley   +1 more source

Editorial: Memory – Humanities and Social Sciences Contexts

Horyzonty Wychowania, 2017
Memory  is one of the essential concepts of science and it is presents in scientific works of psychology, pedagogy, sociology, linguistics, history, cultural studies, and also i.e.
Bożena Sieradzka-Baziur
doaj  

Why are social sciences and humanities needed in the works of IPBES? A systematic review of the literature

The Innovation, 2018
Despite the increased attention, which has been given to the issue of involving knowledge and experts from the social sciences and humanities (SSH) into the products and works of the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem
A. Vadrot, A. Ranković, R. Lapeyre, P. Aubert, Y. Laurans   +4 more
semanticscholar   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Health professionals prepared for the future. Why Social Sciences and Humanities teaching in Medical Faculties matter

MedEdPublish, 2018
A public debate took place place in France in 2018 concerning ethical and social issues of biomedicine and life science and technologies. As faculty members of French medical schools and scholars in Social Sciences and Humanities, we contributed to ...
Nicolas Lechopier, Gilles Moutot, Céline Lefève, Maria Teixeira, Roberto Poma, Guillaume Grandazzi, Anne Rasmussen   +6 more
doaj  

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

A current view of the Thesis by Publication in the Humanities and Social Sciences

, 2018
Aim/Purpose The aim of this study is to further our collective understanding of the practicalities and possibilities of the Thesis by Publication (TBP) in the disciplinary context of the Humanities and Social Sciences (HSS) in Australia.
S. Mason, M. Merga
semanticscholar   +1 more source

Addressing disparities in European Social Sciences & Humanities research on climate, energy and mobility: insights from a Call for Evidence survey and analysis workshops on the challenges and opportunities of working in Southern and Central & Eastern Europe. [PDF]

Open Res Eur, 2023
Foulds C, Crowther A, Sorman AH, Cabello V, Bálint D, Tagai G, Varjú V, Robison R, Sánchez EG, Zindulková K.   +9 more
europepmc   +1 more source