Results 121 to 130 of about 4,980,752 (357)

Paradigm Shift in Social Science Research: A General Perspective

, 2023
Vijay Aryal
openalex   +2 more sources

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

The Status Of Sociology As A Fundamental Social Science At Modern University

Društvene i Humanističke Studije, 2018
The modern university is a subject to notable changes during three previous decades. The Bologna concept of higher education is primarily focused on market principles and thus has caused stagnation in the field of social sciences and humanities, because ...
Biserka R. Košarac
doaj  

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

Understanding the work of general practitioners: a social science perspective on the context of medical decision making in primary care [PDF]

, 2008
Robert Geneau, Pascale Lehoux, Raynald Pineault, Paul A. Lamarche   +3 more
openalex   +1 more source

Classifications of Sociological Paradigms

Encyclopedia
In this entry paper, we propose a brief analysis of the use of the notion of “paradigm” in sciences in general and in social sciences and sociology in particular.
Alexandru-Cosmin Apostol, Romeo Asiminei
doaj   +1 more source

Survey of Theory-building Barriers in Social Sciences Area [PDF]

‫مدیریت بازرگانی, 2009
Social Sciences with such topics as human behavior, groups and communities, and in general deal with human and social systems. These subjects are very dynamic and variable, and form in complex interactions network.
Ali Asghar Pour Ezzat, Parisa Rezaeei, Hamid Reza Yazdani   +2 more
doaj  

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

Molecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
wiley   +1 more source

Social Life of Values [PDF]

The case of the Danish “cartoon war†was a premonition of things to come: accelerated social construction of inequalities and their accelerated symbolic communication, translation and negotiation.
Magala, S.J.
core   +1 more source