Results 121 to 130 of about 4,094,474 (305)
Zipf's law, Hierarchical Structure, and Shuffling-Cards Model for Urban Development
A new angle of view is proposed to find the simple rules dominating complex systems and regular patterns behind random phenomena such as cities. Hierarchy of cities reflects the ubiquitous structure frequently observed in the natural world and social ...
Chen, Yanguang
core +2 more sources
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Objetividade e subjetividade nas ciências jurídicas e sociais: Durkheim e Weber
Revista da Faculdade de Direito da Universidade de Uberlândia, 2010 The birth of social sciences in the nineteenth century was marked by the reflection on the specific method that these sciences should conform, at the same time by the concern to give the autonomous meaning of causal relationships between social facts in ...
Cesar Antonio Serbena
doaj
Self-organisation or Selfcreation? From Social Physics to Realist Dynamics [PDF]
The currently fashionable theory of self-organisation has its origins in statistical physics. Many believe that the underlying physics model, which is based on inanimate systems, can be employed to explain and predict the emergence of social structures ...
Graeme Donald Snooks
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
BJGP OpenBackground: Since the COVID-19 pandemic, there has been an increase in the use of remote consultations in general practice in the UK. This leads to the displacement of the consultation outside of the physical general practice, and its ‘emplacement ...
Ada Humphrey +3 more
doaj +1 more source
Library and information education at Islamic universities in Indonesia: Obstacles and opportunities [PDF]
The Library and Information Studies programs at Islamic universities in Indonesia were born from the idealism thought that the advent of globalization era is a reality fact that we have no choice but to face and anticipate it.
Farida, Ida, Purnomo, Pungki
core
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
A proposal for measuring the benefits of policy-oriented social science research: [PDF]
This paper addresses the problem of how to measure the benefits of policy-oriented social science research. It argues that social science research promotes economic efficiency in three different ways—it fosters efficiency in the public sector both ...
Park, Donghyun
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source