Results 121 to 130 of about 4,056,302 (306)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
The Political Opinions of Swedish Social Scientists [PDF]
We study the political opinions of Swedish social scientists in seven disciplines. A survey was sent to 4,301 academics at 25 colleges and universities, which makes the coverage of the disciplines included more or less comprehensive.
Berggren, Niclas +2 more
core +3 more sources
Self-organisation or Selfcreation? From Social Physics to Realist Dynamics [PDF]
The currently fashionable theory of self-organisation has its origins in statistical physics. Many believe that the underlying physics model, which is based on inanimate systems, can be employed to explain and predict the emergence of social structures ...
Graeme Donald Snooks
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A Shrinking Minority: The Continuing Decline of Gun Ownership in America [PDF]
, 2007 Contrary to public claims by the gun industry and the gun lobby, firearms ownership has declined dramatically over the past 35 years according to new survey data from the General Social Survey (GSS) released today by the National Opinion Research Center (
Josh Sugarmann
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Predictability of mobile phone associations [PDF]
, 2010 Prediction and understanding of human behavior is of high importance in many modern applications and research areas ranging from context-aware services, wireless resource allocation to social sciences.
Hansen, Lars Kai +4 more
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Generative Adversarial Networks in Business and Social Science
Applied SciencesGenerative adversarial networks (GANs) have become a recent and rapidly developing research topic in machine learning. Since their inception in 2014, a significant number of variants have been proposed to address various topics across many fields, and they have particularly excelled not only in image and language processing but also in the medical and ...
África Ruiz-Gándara +1 more
openaire +4 more sources
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Resource Guide in Exploring Ethics: A Practical Resource Guide for Tutors and Students [PDF]
, 2009 This resource guide will help staff and students who are studying social sciences in hospitality, tourism, entertainment, events, leisure. It outlines the ethical issues that they need to consider when conducting research for their dissertation or for ...
Kenyon, AJ, Wood, E
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