Results 151 to 160 of about 3,824,520 (347)

Tecnología Y Sociedad: Un Contrapunto Armónico

open access: yesRevista de Estudios Sociales, 2005
The author affirms that general understanding has been affected by the separation between both cultures—i.e. social sciences and natural sciences—. In this sense he pleads for their unification stating that, in order to narrate the course of history ...
José Luis Villaveces
doaj  

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

Habitus and Reflexivity: Restructuring Bourdieu's Theory of Practice [PDF]

open access: yes
Contrary to Bourdieu\'s thesis, it is not only when a subject\'s habitus does not fit a field\'s positions that s/he becomes more reflexive. Reflexivity is also enhanced by intra-habitus tensions, by more general incongruences between dispositions ...
Nicos Mouzelis
core  

Multi‐omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Using multi‐omic characterization, we aimed to identify key regulators specific to squamous cell lung carcinoma (SqCC). SqCC‐specific differentially expressed genes were integrated with metabolics data. High expression of the creatine transporter SLC6A8, along with elevated creatine levels, appeared to be a distinct metabolic feature of SqCC.
Johan Staaf   +10 more
wiley   +1 more source

Constructing a General Theory of Life: The Dynamics of Human and Non-human Systems [PDF]

open access: yes
The ultimate objective of theorists studying living systems is to construct a general theory of life that can explain and predict the dynamics of both human and nonhuman systems. Yet little progress has been made in this endeavour. Why?
Graeme Donald Snooks
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Rational Choice, Scientific Method and Social Scientism [PDF]

open access: yes
The eighteenth-century introduction of the scientific method of the natural sciences to the study of social phenomena draws a line between moral philosophy Ethat aspect of ancient and medieval philosophy that dealt with social issues Eand the social ...
Bongo Adi   +2 more
core  

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