Results 51 to 60 of about 11,310,500 (395)

An Unusual Case of Severe Pneumonia Caused Due With a Favorable Clinical Response to Antifungals in a Nonimmunocompromised Patient From the Community

Journal of Investigative Medicine High Impact Case Reports, 2023
Severe pneumonia due to Candida tropicalis infection mainly occurs in immunosuppressed patients or those currently receiving broad-spectrum antibiotics. Herein, we report a case of severe pneumonia caused due to C tropicalis in an elderly patient.
Killen H. Briones-Claudett MD, MSc, H. Mónica Briones-Claudett MSc, MD, Roger Alexander Murillo Vasconez MD, Cynthia K. Bajaña Huilcapi MD, Carolina del Rosario Rivera Salas MD, Jaime Benitez Sólis MD, MSc, Domenica F. Estupinan Vargas MD, Henry Parra-Vera MSc, Killen H. Briones Zamora MS, Diana C. Briones Marquez MD, Michelle Grunauer MD, PhD   +10 more
doaj   +1 more source

Social Security and Longevity [PDF]

SSRN Electronic Journal, 2005
Many countries face the problem of how to reform social security systems to cope with increasing life expectancy. This raises questions concerning both distribution and risk sharing across generations. These issues are addressed within an OLG model with stochastic life expectancy across generations and endogenous retirement decisions.
openaire   +4 more sources

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

O-38 FULMINANT WILSON: A WELL-DEFINED ENTITY. HOW TO DIAGNOSE IT QUICKLY TO PREVENT MORTALITY

Annals of Hepatology, 2023
Introduction and Objectives: Mccullough published in 1983 a series of 3 cases from the Mayo Clinic and nine from the rest of the world, proposing a specific clinical entity of Wilson´s disease (WD) with a fatal outcome if not transplanted. Costa Rica has
Francisco Hevia, Mónica Penón, Stephanie Lotz, Alfredo Mora, Gabriela Jiménez, Ramsés Badilla, Mildred Jiménez, Manuel Saborío, Karina Hidalgo, Adrián González, Francisco Vargas, Wagner Ramirez, Esteban Cob, Aldo Carvajal, Ana Lorena Madrigal, José Pablo Cortes, Jorge Vargas, Danny Alvarado   +17 more
doaj  

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Coronavirus Disease 2019 in Patients With End-Stage Kidney Disease on Hemodialysis in Guatemala

Kidney International Reports, 2021
Introduction: Coronavirus disease 2019 (COVID-19) is public health concern across the world. Data on the epidemiology among patients on hemodialysis in Latin America and low- and middle-income countries are limited.
Regina Sosa, Pablo Garcia, Ever O. Cipriano, Agualuz Hernández, Elmer E. Hernández, Paola I. Chavez, Angélica Manchinelli, Oscar A. Morales, Lourdes E. Flores, Hair J. Romero, Yulany Raquec, Byron F. Sapón, Kevin E. Soch, Shuchi Anand, Vicente Sánchez-Polo   +14 more
doaj  

Social Security Primer [PDF]

, 2016
[Excerpt] This report provides an overview of Social Security financing and benefits under current law. Specifically, the report covers the origins and a brief history of the program; Social Security financing and the status of the trust funds; how ...
Nuschler, Dawn
core   +1 more source

Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation

Molecular Oncology, EarlyView.
Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza, Robert Carlsson, Coralie Gamper, Gayatri Chitale, Johan Bengzon, Gesine Paul   +5 more
wiley   +1 more source

Social Security Reform: Legal Analysis of Social Security Benefit Entitlement Issues [PDF]

, 2013
[Excerpt] Calculations indicating that in the long run the Social Security program will not be financially sustainable under the present statutory scheme have fueled the current debate regarding Social Security reform.
Nicola, Thomas J, Swendiman, Kathleen S
core   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source