Results 121 to 130 of about 398,723 (286)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Exploring the Linkage of Spatial Indicators from Remote Sensing Data with Survey Data: The Case of the Socio-Economic Panel (SOEP) and 3D City Models [PDF]
This paper demonstrates the spatial evaluation of survey data from the German Socio-Economic Panel (SOEP) study using geo-coordinates and spatially relevant indicators from remote sensing data.
Gert G. Wagner, Jan Goebel, Michael Wurm
core
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Toward Integrated Urban Observatories: Synthesizing Remote and Social Sensing in Urban Science
Remote SensingUrbanization is reshaping landscapes and posing unprecedented sustainability challenges, necessitating more integrative approaches to urban observation. This review synthesizes recent advancements in traditional remote sensing and emerging social sensing
Danlin Yu
doaj +1 more source
Social issues and implications of remote sensing applications: Paradigms of technology transfer [PDF]
The transfer of technology from one federal agency to another was observed in the case of the move of LANDSAT to NOAA. An array of unanticipated consequences was found that have important impacts on both the process and outcome of the transfer.
Hoos, I. R.
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
The Comparison of the Efficieny of MCDM Models in site Selection of Flood Spread in GIS Environment (Case Studey: Garabaygan Catchment) [PDF]
نشریه جغرافیا و برنامهریزی, 2014 The selection of suitable location for implementing of flood spreading project and artificial recharge of aquifers is an important step. To assess this purpose, the Geographic Information System (GIS) conceptual models and decision making systems were ...
Hasan ali Faraji Sabokbar +3 more
doaj