Results 41 to 50 of about 5,221,339 (294)

Novel Genetic Risk Factor Identified for L‐Asparaginase‐Induced Pancreatitis in Pediatric Patients With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background L‐asparaginase is a critical component in treatment protocols for pediatric acute lymphoblastic leukemia. Acute pancreatitis reactions can necessitate delays and, in some cases, discontinuation of L‐asparaginase, which compromises outcomes.
Edward J. Raack, Wan‐Chun Chang, Miguel Cordova‐Delgado, Spencer J. Anderson, Jessica N. Trueman, Erika N. Scott, Catrina M. Loucks, Shahrad R. Rassekh, Gabriella S. S. Groeneweg, Michelle Higginson, Kathy Li, Fudan Miao, Derek Yau, Donna Johnston, Mounira Ibrahim, Maja Krajinovic, Thai Hoa Tran, Jessica Tewfik, Jean‐François Bussières, Thaïna‐Rafi Jean‐Baptiste, Denis Lebel, Lucie Pecheux, Bina Gyawali, Gregory Guilcher, Gesche Riabowol, Geert ’t Jong, Michelle Staub, Geoff Cuvelier, Kathleen Felton, Sara Khalaj, Michael Rieder, Awatif Abuzgaia, Tamorah Lewis, Himal Ghimire, Paul Nathan, Kerry Goralski, Ketan Kulkarni, Zara Forbrigger, Colin J. D. Ross, Bruce C. Carleton   +39 more
wiley   +1 more source

State and Current Trends in the Development of the Social Service System in Russia

Economies, 2022
The paper assesses the current state and development trends of the social service system. The authors presented the current scheme of the system of social services in Russia and determined that it includes the budgetary, non-profit and commercial sectors.
Maxim A. Shestakov, Vladimir M. Smirnov, Marina V. Danilina   +2 more
doaj   +1 more source

Building social capital through breastfeeding peer support: Insights from an evaluation of a voluntary breastfeeding peer support service in North-West England [PDF]

, 2015
Background: Peer support is reported to be a key method to help build social capital in communities. To date there are no studies that describe how this can be achieved through a breastfeeding peer support service.
A Aiken, A Faulkner, A Hofmeyer, A Portes, AM Ziersch, B Berg, B Rossman, BJ Rossman, CH Hsieh, CL Dennis, CW Chang, D Narayan, D Wade, Department of Health, Department of Health, Department of Health, E Cox, E Uphoff, EM Uslaner, ER Meier, F Baum, F Dykes, F Dykes, F McAndrew, G Thomson, G Thomson, G Thomson, G Thomson, Gill Thomson, I Kawachi, J Ingram, J Laurinkari, J Rappaport, JA Scott, K Dutt, K Jolly, K McKenzie, K Woodman, Kirsty Hymers, L Berkham, L Dyson, L Larsen, L Mayoux, L Prusak, LH Gunderson, M Kirkham, M Woolcock, M Woolcock, M Woolcock, M Woolcock, MA Boneham, Marie-Clare Balaam, MJ Renfrew, MJ Renfrew, N Crossland, NICE, NM Moolenaar, P Bourdieu, P Curtis, P Dekker, P Hoddinott, P Raine, R Griffiths, R Putman, R Putnam, RD Putnam, RD Putnam, RJ McInnes, RJ McInnes, RL Hawkins, RM Carpiano, S Cohen, S Fetter, S Knack, S Szreter, SEL Wakefield, SL Brown, T Hancock, V Braun, W Poortinga, WHO   +80 more
core   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Visual Acuity Improvement of Cataract Patients After Cataract Surgery at Sumbawa Hospital in 2018

Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement), 2022
A cataract is the most common cause of vision impairment and blindness worldwide. The Rapid Assessment of Avoidable Blindness survey held in 2014 - 2016 showed that the prevalence of blindness in West Nusa Tenggara was the second highest in Indonesia ...
Siska Takarai, I Wayan Gede Jayanegara, Anak Agung Mas Putrawati Triningrat, Ni Made Ari Suryathi, Ariesanti Tri Handayani, Anak Agung Ayu Sukartini Djelantik, Angelo Doniho, Anthea Casey, Giovani Faustine   +8 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Whose outcomes are they anyway? Report of the pilot evaluation of a joint service\ud [PDF]

, 2011
Health and social care partnership working is often predicated on the notion that it improves outcomes for service users. Yet there is a lack of evidence linking partnerships to changes in outcomes. Against this background, the Health Services Management
Dickinson, Helen, Glasby, Jon, McCarthy,, Linda, Miller, Robin   +3 more
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Improving mental health outcomes: achieving equity through quality improvement

, 2014
Objective. To investigate equity of patient outcomes in a psychological therapy service, following increased access achieved by a quality improvement (QI) initiative. Design.
A. J. Poots, Benneyan, Commander, D. Bell, Dietrich, E. Honeybourne, J. Green, Kroenke, L  we, Peters, R. Barnes, S. A. Green, T. Woodcock, Thor   +13 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source