Results 81 to 90 of about 5,221,339 (294)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

The Design and Implementation of a Video-facilitated Transdisciplinary STEM Curriculum in the Context of Covid-19 Pandemic

Educational Technology & Society, 2022
The COVID-19 pandemic has brought disruptions and constraints to K-12 STEM education, such as the shortened classroom time and the restrictions on classroom interactions.
Biyun Huang, Morris Siu-Yung Jong, Ching Sing Chai   +2 more
doaj  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Podcast episode 5: Theology, Public Health, and Social Service [PDF]

, 2018
This article and podcast was originally published in The Prophet -- a journal created by and for the students at the Boston University School of Theology (BUSTH) to amplify the voices of STH students by promoting and sharing a range of perspectives on ...
Boss, Kathy, Ona, Fernando
core  

Hikester - the event management application

, 2018
Today social networks and services are one of the most important part of our everyday life. Most of the daily activities, such as communicating with friends, reading news or dating is usually done using social networks.
Khatipov, Rinat, Mazzara, Manuel, Negimatzhanov, Aydar, Rivera, Victor, Zakirov, Anvar, Zamaleev, Ilgiz   +5 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Federal Employees’ Retirement System: The Role of the Thrift Savings Plan [PDF]

, 2015
[Excerpt] Federal employees participate in one of two retirement systems. The Civil Service Retirement System (CSRS) was established in 1920 and covers only employees hired before 1984.
Isaacs, Katelin P
core   +2 more sources

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

METHODOLOGICAL AND PROGRAM PECULIARITIES OF USAGE OF SOCIAL SERVICES IN DISTANCE LEARNING SYSTEMS

Ìнформаційні технології в освіті, 2012
In article the methodological and software peculiarities of social services usage in distance learning system “Kherson Virtual University” is considered.
O. Gnedkova, V. Lyakutin
doaj  

SOCIAL SCIENCE IN THE EXTENSION SERVICE [PDF]

Teaching/Communication/Extension/Profession,
Miller, Paul A.
core   +1 more source