Results 81 to 90 of about 5,370,301 (294)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

More effective social services [PDF]

open access: yes
In June 2014, the Productivity Commission was asked to look at ways to improve how government agencies commission and purchase social services. The final report was released in mid-September 2015. It makes several recommendations about how to make social
Graham Scott   +2 more
core  

The early years of innovative approaches to youth information and counselling [PDF]

open access: yes, 2012
This chapter focuses on the innovative services set up for the specific purpose of giving social support to young people by means of information and counselling in youth information and counselling services.
Faché, Willy
core   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

Shaping the criminal justice system: the role of those supported by Criminal Justice Service [PDF]

open access: yes, 2012
In Scotland, the development and delivery ofpersonalised social work services has been part of a wider public service reform agenda, building on Changing lives: report of the 21st century review of social work (Scottish Executive, 2006).
Lightowler, C., Weaver, Beth
core  

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

open access: yesMolecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian   +10 more
wiley   +1 more source

Marketing of Library Services and Products through Social Media: An Evaluation [PDF]

open access: yes, 2013
Social media has a great impact on information promotional activities by bringing tremendous changes in the field of marketing. Social networking applications help the users to possess interconnections among the community members and remix the library ...
Gireesh Kumar, T. K., Muruli, N
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Evaluation of a Pilot Intervention to Relink Formerly Incarcerated PLHWHAs to HIV/AIDS Care

open access: yesFlorida Public Health Review, 2018
HIV is a manageable chronic disease. However, it requires knowing one’s status, retention in care, and medication adherence for viral suppression. Disadvantaged groups of persons living with HIV/AIDS (PLWHAs) who experience incarceration and major ...
Graham F. Watts, Sr.   +4 more
doaj  

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