Results 41 to 50 of about 939,207 (357)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Frontiers in Veterinary Science, 2022 BackgroundEffective biosecurity communication of transmission risks and associated protective behaviors can reduce the impacts of infectious diseases in US animal agriculture.
Tung-Lin Liu +26 more
doaj +1 more source
The Role of Spatial Interaction in Social Networks [PDF]
, 2012 This article addresses the role of spatial interaction in social networks. We analyse empirical data describing a network of leisure contacts and show that the probability to accept a person as a contact scales in distance with similar to d (-aEuro parts
Flötteröd, Gunnar +2 more
core +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Frontiers in Psychology, 2019 In general, dreams are a novel but realistic simulation of waking social life, with a mixture of characters, motivations, scenarios, and positive and negative emotions.
Mark Blagrove +7 more
doaj +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Flood Risk and Preventive Choices: A Framework for Studying Human Behaviors
Behavioral SciencesThe topic of flood phenomena has always been of considerable importance due to the high risks it entails, both in terms of potential economic and social damage and the jeopardizing of human lives themselves.
Alessandro Sapienza, Rino Falcone
doaj +1 more source
SOCIAL IMPACT ASSESSMENT BY SOCIAL SIMULATION [PDF]
Impact Assessment, 1986 ABSTRACT Social simulation is a methodology, in which real social interaction is generated under simulated conditions, representing the reference system. Models have been developed for production organizations, science policy advisory councils and governmental bureaucracies.
openaire +1 more source
Social Embeddedness and Agent Development [PDF]
, 1998 Two different reasons for using agents are distinguished: the `engineering' perspective and the `social simulation' perspective. It is argued that this entails some differences in approach.
Edmonds, Bruce
core
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source