Results 91 to 100 of about 818,076 (297)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Grammar, cohesion and the co-ordination of the “self” in a current psychotherapeutic technique

Journal of World Languages
This paper aims to show how concepts and analytical methods of systemic functional linguistics can work congruently with other human practices to improve outcomes for those undergoing the suffering around loss of meaning and the absence of purposeful ...
Butt David G., Moore Alison R., Henderson-Brooks Caroline, Khoo Kristin   +3 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Error Reporting among Nurses Working at Yasuj Shahid Beheshti Hospital in 2014

نشریه پرستاری ایران, 2016
Background & Aims: Nursing report is one of the important documents in a patients’ record and it is also the best tool which can help to evaluate the nurses’ activities in 24-hour periods.
E Nouhi, A Dehbanizadeh, M Zoladl, KH Saeedi, A Paghan   +4 more
doaj  

Impact of Data Element Utilization Level on Enterprises' Supply Chain Discourse Power [PDF]

Nongye tushu qingbao xuebao
[Purpose/Significance] In the digital age, data elements have become a key factor in production, while insufficient bargaining power in the supply chain poses significant operational risks to enterprises.
LIU Ting, LIU Shuhan, LIU Zhenyan, ZENG Dequan, HU Yuan
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Skills dialogue social inclusion Northern Ireland

, 2002
Includes bibliographical references. Title from cover. - Running title: Social inclusion partnership; sector skills dialogue reportAvailable from British Library Document Supply Centre- DSC:m03/14173 / BLDSC - British Library Document Supply ...
Great Britain. Department for Education and Skills (United Kingdom), Consultancy Mentoring Works (United Kingdom)   +1 more
core  

Tangible outcomes of internet use: from digital skills to tangible outcomes project report [PDF]

, 2015
In the past decade, digital divide discussions have moved from discussions of use or non-use, to a more nuanced recognition of different types and levels of access, motivation, skills and Internet use in a discourse that centres around digital inclusion ...
Helsper, Ellen J., Ellen J. Helsper, van Deursen, Alexander Johannes Aloysius Maria, Eynon, Rebecca, Rebecca Eynon, Alexander van Deursen   +5 more
core  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source